Open AccessArticle
Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
by
Tatiane C. Carvalho, Marília R. Simão, Sérgio R. Ambrósio, Niege A. J. C. Furtado, Rodrigo C. S. Veneziani, Vladimir C. G. Heleno, Fernando B. Da Costa, Brenda P. F. A. Gomes, Maria Gorete M. Souza, Erika Borges dos Reis and Carlos H. G. Martins
Cited by 50 | Viewed by 12164
Abstract
Six pimarane-type diterpenes isolated from
Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated
in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibitory concentration (MIC) and
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Six pimarane-type diterpenes isolated from
Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated
in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against
Porphyromonas gingivalis,
Prevotella nigrescens,
Prevotella intermedia,
Prevotella buccae,
Fusobacterium nucleatum,
Bacteroides fragilis,
Actinomyces naeslundii,
Actinomyces viscosus,
Peptostreptococcus micros,
Enterococcus faecalis and
Aggregatibacter actinomycetemcomitans. The compounds
ent-pimara-8(14),15-dien-19-oic acid, its sodium salt and
ent-8(14),15-pimaradien-3β-ol were the most active, displaying MIC values ranging from 1 to 10 μg mL
-1. The results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new chemicals for use as a complement to instrumental endodontic procedures.
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