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Keywords = Ulva pertusa Kjellman (U. pertusa)

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9 pages, 1186 KiB  
Article
Oral Administration of Ulva pertusa Kjellman Improves Intestinal Motility Against Loperamide-Induced Constipation in Mice
by Eun-Jeong Koh, In-Yung Sunwoo, Yong-Kyun Ryu, Won-Kyu Lee, Taeho Kim and Woon-Yong Choi
Appl. Sci. 2024, 14(21), 9892; https://doi.org/10.3390/app14219892 - 29 Oct 2024
Viewed by 1016
Abstract
Ulva pertusa Kjellman (U. pertusa) is a seaweed indigenous to the intertidal zone of the Korean coastline. U. pertusa exhibits immune-enhancing and antitumor activities, and its effects on intestinal health have gained attention. However, the mechanisms underlying its beneficial effects on intestinal [...] Read more.
Ulva pertusa Kjellman (U. pertusa) is a seaweed indigenous to the intertidal zone of the Korean coastline. U. pertusa exhibits immune-enhancing and antitumor activities, and its effects on intestinal health have gained attention. However, the mechanisms underlying its beneficial effects on intestinal physiology remain elusive. Here, the effect of U. pertusa intake in ameliorating loperamide-induced constipation in male mice was evaluated. Additionally, cellular levels of proinflammatory cytokines, including nuclear factor-kB and interleukin-1β, were assessed to decipher the intricate interplay between inflammation and improvements in bowel movement. U. pertusa intake increased fecal weight and water content and improved the intestinal transit rate. Moreover, it reduced the levels of proinflammatory cytokines, possibly via short-chain fatty acids implicated in modulating intestinal motility and mucosal inflammation. These findings underscore the efficacy of U. pertusa in improving bowel motility and intestinal functionality, and its potential in ameliorating constipation. Full article
(This article belongs to the Special Issue New Advances in Functional Foods and Nutraceuticals)
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