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Keywords = UGGTC ratio

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15 pages, 492 KiB  
Article
Urinary Gamma-Glutamil Transferase as an Early Biomarker of Renal Disease in Dogs with Leishmaniosis
by Patricia Ruiz, Inmaculada Sevidane, Angela Durán, Ana Belén García, Beatriz Macías-García and Rafael Barrera
Vet. Sci. 2025, 12(5), 436; https://doi.org/10.3390/vetsci12050436 - 2 May 2025
Viewed by 669
Abstract
Canine leishmaniosis, caused by Leishmania infantum, is a zoonotic disease often leading to chronic kidney disease (CKD). Early detection of renal damage is critical for prognosis and treatment, as conventional biomarkers, such as serum creatinine and symmetric dimethylarginine (SDMA), are inadequate for [...] Read more.
Canine leishmaniosis, caused by Leishmania infantum, is a zoonotic disease often leading to chronic kidney disease (CKD). Early detection of renal damage is critical for prognosis and treatment, as conventional biomarkers, such as serum creatinine and symmetric dimethylarginine (SDMA), are inadequate for detecting early stages of renal dysfunction. This study evaluates the urinary gamma-glutamyl transferase-to-creatinine ratio (uGGT/c) as an early biomarker for renal injury in dogs with leishmaniosis, including 17 healthy dogs and 77 dogs with leishmaniosis, categorized using the International Renal Interest Society (IRIS) guidelines. Plasma and urinary parameters, including uGGT/c, were analyzed. Elevated uGGT/c ratios were observed in over 50% of non-azotemic and non-proteinuric dogs and all dogs with mild-to-moderate proteinuria. The uGGT/c ratio demonstrated a 90.4% sensitivity and 80% specificity for early detection of renal tubular damage, outperforming plasma creatinine (44.2%) and SDMA (51.9%). The uGGT/c ratio correlated strongly with proteinuria (UPC; r = 0.716, p < 0.001) and SDMA (r = 0.591, p < 0.001), indicating its usefulness as an early indicator of renal dysfunction. Despite the small sample size, the implementation of the uGGT/c ratio as promising biomarker could improve early diagnosis and clinical intervention, helping to avoid irreversible renal damage in dogs affected by leishmaniosis. Full article
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9 pages, 441 KiB  
Communication
Potential Acute Renal Injury in Sheep with Bluetongue Serotype 4
by Labrini V. Athanasiou, Eleni G. Katsogiannou, Victoria M. Spanou, Anna Dedousi and Panagiotis D. Katsoulos
Pathogens 2021, 10(2), 159; https://doi.org/10.3390/pathogens10020159 - 3 Feb 2021
Cited by 4 | Viewed by 2556
Abstract
Bluetongue is a vector-borne disease with epidemic potential. Recently, outbreaks of Bluetongue were reported across Greece, caused by the Bluetongue virus (BTV) serotype 4. Regarding its pathogenesis, BTV infection involves various target organs with limited data referring to the kidneys. The objective of [...] Read more.
Bluetongue is a vector-borne disease with epidemic potential. Recently, outbreaks of Bluetongue were reported across Greece, caused by the Bluetongue virus (BTV) serotype 4. Regarding its pathogenesis, BTV infection involves various target organs with limited data referring to the kidneys. The objective of this study was to identify the possible impact of BTV infection on kidneys using common renal biomarkers. Urine and blood samples collected from 30 sheep with clinical signs of bluetongue (BTV sheep) and 30 clinically healthy sheep (normal sheep) from the same farms were finally selected and included in the study from an initial population of 47 sheep per group, based on the absence of active urine sediment. Complete urinalysis was performed and urine protein to creatinine ratio (UPC) and urine gamma-glutamyl transferase to creatinine (UGGTC) ratio were determined. Blood urea nitrogen (BUN), creatinine, total proteins, albumin (ALB), and inorganic phosphate (P) were determined in serum samples. UPC and UGGTC were significantly higher (p < 0.05) in BTV sheep compared to normal, whereas urine specific gravity (USG) was significantly lower (p < 0.05). Cylindruria was also detected in BTV sheep, and absence of azotemia in BTV and normal sheep. All these findings are indicative of renal tubular injury and/or dysfunction and suggestive of an association between BTV infection and acute damage of renal tissue. Full article
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