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Keywords = Tunisian muscular dystrophy

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13 pages, 1198 KiB  
Review
An Update of Clinical, Epidemiological, and Psychosocial Features in Gamma-Sarcoglycanopathy
by Naoufel Chabbi, Corrado Angelini and Alicia Aurora Rodriguez
Muscles 2023, 2(2), 164-176; https://doi.org/10.3390/muscles2020012 - 3 Apr 2023
Cited by 4 | Viewed by 3459
Abstract
Limb-girdle muscular dystrophies (LGMDs) represent a group of muscle diseases due to monogenic mutations encoding muscle proteins that are defective for heterozygous and homozygous mutations prevalent in certain regions. Advances in knowledge of their pathophysiology have shed light on these rare diseases, which [...] Read more.
Limb-girdle muscular dystrophies (LGMDs) represent a group of muscle diseases due to monogenic mutations encoding muscle proteins that are defective for heterozygous and homozygous mutations prevalent in certain regions. Advances in knowledge of their pathophysiology have shed light on these rare diseases, which were, until recently, difficult to diagnose. This paper has described the process of diagnosis in autosomal recessive limb-girdle dystrophy that in Tunisia are due to the c.521del mutation in gamma-sarcoglycanopathy and to ethnically specific mutations in other countries such as Italy. The epidemiology, pathophysiology clinical features, and the main socioeconomic needs as well as research progress are discussed. We discuss an Italian case for its psychosocial impact and socioeconomic consideration and compare this case with Tunisian patients. Full article
(This article belongs to the Special Issue Feature Papers in Muscles)
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