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Keywords = Talaromyces mangshanicus

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11 pages, 1805 KiB  
Article
New Secondary Metabolites from the Marine-Derived Fungus Talaromyces mangshanicus BTBU20211089
by Kai Zhang, Xinwan Zhang, Rui Lin, Haijin Yang, Fuhang Song, Xiuli Xu and Long Wang
Mar. Drugs 2022, 20(2), 79; https://doi.org/10.3390/md20020079 - 18 Jan 2022
Cited by 21 | Viewed by 2739
Abstract
Seven new compounds, namely talaromanloid A (1), talaromydene (2), 10-hydroxy-8-demethyltalaromydine and 11-hydroxy-8-demethyltalaromydine (3 and 4), talaromylectone (5), and ditalaromylectones A and B (6 and 7), together with seven known compounds were identified from [...] Read more.
Seven new compounds, namely talaromanloid A (1), talaromydene (2), 10-hydroxy-8-demethyltalaromydine and 11-hydroxy-8-demethyltalaromydine (3 and 4), talaromylectone (5), and ditalaromylectones A and B (6 and 7), together with seven known compounds were identified from a marine-derived fungus, Talaromyces mangshanicus BTBU20211089, which was isolated from a sediment sample collected from the South China Sea. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D, and 2D NMR techniques. The absolute configurations of 1 and 2 were elucidated by comparing experimental and calculated ECD spectra. Compounds 1, 2, 6, and 7 are new compounds possessing a novel carbon skeleton. Compound 6 is a dimeric molecule of 3 and 9. Compound 7 shared a unique structure of the cyclized dimer of 3 and 4. All the compounds were tested for their bioactivities against Staphylococcus aureus, Escherichia coli, and Candida albicans. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Sediment Derived Fungi)
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