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Keywords = TREM2 sensors

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32 pages, 1448 KB  
Review
Therapeutic Targets in Innate Immunity to Tackle Alzheimer’s Disease
by Maria L. Serradas, Yingying Ding, Paula V. Martorell, Ida Kulińska and Sergio Castro-Gomez
Cells 2024, 13(17), 1426; https://doi.org/10.3390/cells13171426 - 26 Aug 2024
Cited by 8 | Viewed by 5646
Abstract
There is an urgent need for effective disease-modifying therapeutic interventions for Alzheimer’s disease (AD)—the most prevalent cause of dementia with a profound socioeconomic burden. Most clinical trials targeting the classical hallmarks of this disease—β-amyloid plaques and neurofibrillary tangles—failed, showed discrete clinical effects, or [...] Read more.
There is an urgent need for effective disease-modifying therapeutic interventions for Alzheimer’s disease (AD)—the most prevalent cause of dementia with a profound socioeconomic burden. Most clinical trials targeting the classical hallmarks of this disease—β-amyloid plaques and neurofibrillary tangles—failed, showed discrete clinical effects, or were accompanied by concerning side effects. There has been an ongoing search for novel therapeutic targets. Neuroinflammation, now widely recognized as a hallmark of all neurodegenerative diseases, has been proven to be a major contributor to AD pathology. Here, we summarize the role of neuroinflammation in the pathogenesis and progression of AD and discuss potential targets such as microglia, TREM2, the complement system, inflammasomes, and cytosolic DNA sensors. We also present an overview of ongoing studies targeting specific innate immune system components, highlighting the progress in this field of drug research while bringing attention to the delicate nature of innate immune modulations in AD. Full article
(This article belongs to the Collection Molecular Insights into Neurodegenerative Diseases)
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15 pages, 772 KB  
Article
Plasmonic Interferometers as TREM2 Sensors for Alzheimer’s Disease
by Dingdong Li, Rachel Odessey, Dongfang Li and Domenico Pacifici
Biosensors 2021, 11(7), 217; https://doi.org/10.3390/bios11070217 - 1 Jul 2021
Cited by 2 | Viewed by 3529
Abstract
We report an effective surface immobilization protocol for capture of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a receptor whose elevated concentration in cerebrospinal fluid has recently been associated with Alzheimer’s disease (AD). We employ the proposed surface functionalization scheme to design, [...] Read more.
We report an effective surface immobilization protocol for capture of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a receptor whose elevated concentration in cerebrospinal fluid has recently been associated with Alzheimer’s disease (AD). We employ the proposed surface functionalization scheme to design, fabricate, and assess a biochemical sensing platform based on plasmonic interferometry that is able to detect physiological concentrations of TREM2 in solution. These findings open up opportunities for label-free biosensing of TREM2 in its soluble form in various bodily fluids as an early indicator of the onset of clinical dementia in AD. We also show that plasmonic interferometry can be a powerful tool to monitor and optimize surface immobilization schemes, which could be applied to develop other relevant antibody tests. Full article
(This article belongs to the Special Issue Surface Plasmon Resonance for Biosensing)
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