Search Results (3)

Breast cancer is the most common cancer in women globally, often necessitating mastectomy and subsequent breast reconstruction. Silicone mammary implants (SMIs) play a pivotal role in breast reconstruction, yet their interaction with the host immune system and microbiome remains poorly understood. This study investigates the impact of SMI surface topography on host antimicrobial responses, wound proteome dynamics, and microbial colonization. Biological samples were collected from ten human patients undergoing breast reconstruction with SMIs. Mass spectrometry profiles were analyzed for acute and chronic wound proteomes, revealing a nuanced interplay between topography and antimicrobial response proteins. 16S rRNA sequencing assessed microbiome dynamics, unveiling topography-specific variations in microbial composition. Surface topography alterations influenced wound proteome composition. Microbiome analysis revealed heightened diversity around rougher SMIs, emphasizing topography-dependent microbial invasion. In vitro experiments confirmed staphylococcal adhesion, growth, and biofilm formation on SMI surfaces, with increased texture correlating positively with bacterial colonization. This comprehensive investigation highlights the intricate interplay between SMI topography, wound proteome dynamics, and microbial transmission. The findings contribute to understanding host–microbe interactions on SMI surfaces, essential for optimizing clinical applications and minimizing complications in breast reconstruction. Full article

The most common long-term complication of silicone breast implants (SMI) remains capsular fibrosis. The etiology of this exaggerated implant encapsulation is multifactorial but primarily induced by the host response towards the foreign material silicone. Identified risk factors include specific implant topographies. Of note, breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has only been observed in response to textured surface implants. We hypothesize that reduction of SMI surface roughness causes less host response and, hence, better cosmetic outcomes with fewer complications for the patient. A total of 7 patients received the routinely used CPX^®4 breast expander (~60 µM Ra) and the novel SmoothSilk^® (~4 µM Ra), fixed prepectoral with a titanized mesh pocket and randomized to the left or right breast after bilateral prophylactic NSME (nipple-sparing mastectomy). We aimed to compare the postoperative outcome regarding capsule thickness, seroma formation, rippling, implant dislocation as well as comfortability and practicability. Our analysis shows that surface roughness is an influential parameter in controlling fibrotic implant encapsulation. Compared intra-individually for the first time in patients, our data confirm an improved biocompatibility with minor capsule formation around SmoothSilk^® implants with an average shell roughness of 4 µM and in addition an amplification of host response by titanized implant pockets. Full article

Pavement surface texture features are one of key factors affecting the skid resistance of pavement. In this study, a set of stable and reliable texture measurement equipment was firstly assembled by using the linear laser ranging sensor, control system and data acquisition system. Secondly, the equipment was calibrated, and the superposition error of sensor and control system was tested by making a standard gauge block. Thirdly, four different kinds of asphalt mixture were designed, and their surface texture features were obtained by leveraging a three-dimensional laser scanner. Therefore, the surface texture features were characterized as one-dimensional profile features and three-dimensional surface features. At the end of this study, a multi-scale texture feature characterization method was proposed. Results demonstrate that the measurement accuracy of the laser scanning system in the x-axis direction can be controlled ranging from −0.01 mm to 0.01 mm, the resolution in the XY plane is 0.05 mm, and the reconstructed surface model of surface texture features can achieve a good visualization effect. They also show that the root mean square deviation of surface profiles of different asphalt pavements fluctuates greatly, which is mainly affected by the nominal particle size of asphalt mixture and the proportion of coarse aggregate, and the non-uniformity of pavement texture distribution makes it difficult to characterize the roughness of asphalt pavement effectively by a single pavement surface profile. This study proposed a texture section method to describe the 3D distribution of road surface texture at different depths. The macrotexture of the road surface gradually changes from sparse to dense starting from the shallow layer. The actual asphalt pavement texture can be characterized by a simplified combination model of “cone + sphere + column”. By calculating the surface area distribution of macro and microtextures of different asphalt pavements, it was concluded that the surface area of asphalt pavement under micro scale is about 1.8–2.2 times of the cutting area, and the surface area of macrotexture is about 1.4 times of the cutting area. Moreover, this study proposed texture distribution density to characterize the roughness of asphalt pavement texture at different scales. The S_MA index can represent the macroscopic structure level of different asphalt pavements to a certain extent, and the S_MI index can well represent the friction level of different asphalt pavements. Full article