Search Results (6)

This study leverages physical fitness assessment sensors to investigate the effects of a brief in-season break (detraining period) on the physical performance of female basketball players. Sixty-seven players (Senior (n = 19), U18 (n = 19), and U14 (n = 29)) were evaluated before and after a 3-week break using sensor-derived data from a countermovement jump (CMJ), an Abalakov jump (ABK), a linear speed test (20 m sprint), a seated medicine ball throw test (SMBT), and a Basketball-Specific Agility Test (TEA-Basket). The Total Score of Athleticism (TSA), computed as the mean Z-Score across tests, served as a composite indicator of physical fitness. Data obtained from performance sensors revealed significant interactions between time and category for the CMJ, ABK, 20 m sprint, and SMBT, while TEA-Basket measurements showed no significant changes. Time and baseline fitness level interactions were also significant for the CMJ, ABK, and SMBT but not for sprint time or the TEA-Basket. Despite observed declines in explosive strength, speed, and upper-body power across all groups, TSA scores remained stable. These findings underscore the utility of sensor-based evaluation methods in highlighting the adverse effects of short-term detraining and emphasize the necessity of tailored training strategies during competitive breaks. Full article

Background: Rotator cuff-related shoulder pain (RCRSP) is a common musculoskeletal condition characterized by pain, functional disability, reduced mobility, and weakness. There is a need for valid functional tests that can measure shoulder strength and power without exacerbating pain. The Seated Medicine Ball Throw (SMBT) and Unilateral Shot-Put Test (ULSPT) are throwing tests that use a weighted ball in a seated position, measuring throwing distance (m). This study aimed to evaluate the feasibility, discriminative validity, and convergent validity of these tests in individuals with RCRSP. Methods: This cross-sectional study included 64 participants: 30 with RCRSP and 34 asymptomatic controls. Participants completed the QuickDASH and Fear-Avoidance Beliefs Questionnaire (FABQ). Pain was assessed using a 10 cm visual analog scale (VAS) at multiple time points. The SMBT and ULSPT were performed using a 2 kg ball, with throwing distance calculated as the average of three trials. Active shoulder range of motion (AROM) and grip strength were also measured. A two-way mixed-model repeated-measures ANOVA was conducted to examine group effects, with post hoc analyses performed where relevant. Pearson correlations explored associations among outcome measures. Results: The RCRSP group presented with persistent moderate shoulder pain (mean duration = 6.33 ± 5.7 months, VAS = 5.03 ± 1.99 cm, QuickDASH = 26.2 ± 10.54). Pain did not significantly increase after throwing (VAS change = 0.5 ± 1.6 cm, P = 0.4), supporting the tests’ feasibility. ULSPT demonstrated significant differences between the RCRSP and control groups for both symptomatic (2.03 ± 0.81 m) and asymptomatic shoulders (2.04 ± 0.8 m) compared with controls (2.51 ± 0.93 m, P < 0.01). SMBT showed a trend toward group differences (P = 0.05). RCRSP participants showed reduced AROM (166.2 ± 10° vs. 175.1 ± 8.2°) but similar grip strength compared to controls. ULSPT strongly correlated with SMBT (r = 0.92–0.94, P < 0.0001). Both throwing tests correlated moderately with grip strength (r = 0.61–0.81, P < 0.05) and showed mild to moderate correlations with disability, pain, and fear-avoidance measures (r = 0.26–0.48, P < 0.05). Conclusions: The ULSPT demonstrated good discriminative validity in differentiating individuals with RCRSP from controls, while the SMBT showed a trend toward discrimination. Both tests were feasible to administer without significantly exacerbating pain. The strong correlation between ULSPT and SMBT, along with their associations with established measures, supports their potential as functional assessments of upper extremity performance in RCRSP. Full article

Reactive astrogliosis is an early event in the continuum of Alzheimer’s disease (AD). Current advances in positron emission tomography (PET) imaging provide ways of assessing reactive astrogliosis in the living brain. In this review, we revisit clinical PET imaging and in vitro findings using the multi-tracer approach, and point out that reactive astrogliosis precedes the deposition of Aβ plaques, tau pathology, and neurodegeneration in AD. Furthermore, considering the current view of reactive astrogliosis heterogeneity—more than one subtype of astrocyte involved—in AD, we discuss how astrocytic body fluid biomarkers might fit into trajectories different from that of astrocytic PET imaging. Future research focusing on the development of innovative astrocytic PET radiotracers and fluid biomarkers may provide further insights into the heterogeneity of reactive astrogliosis and improve the detection of AD in its early stages. Full article

Ovarian seromucinous tumors (SMBTs) are relatively rare, and their carcinogenesis is largely unknown. In this study, the molecular features of SMBTs in Japan are assessed. DNA was extracted from microdissected paraffin-embedded sections from 23 SMBT cases. Genetic mutations (KRAS, BRAF, PIK3CA, and ERBB2) were evaluated using Sanger sequencing. Immunohistochemistry for p53, ARID1A, and PTEN was also performed as a surrogate for the loss of functional mutations in these tumor suppressor genes. The prevalence of KRAS, BRAF, PIK3CA, and ERBB2 mutations was 4.3% (1/23), 8.6% (2/23), 8.6% (2/23), and 17.3% (4/23), respectively. Overexpression or loss of p53 expression occurred in 26% (6/23), loss of ARID1A expression in 4.3% (1/23), and none of the cases showed expression of PTEN loss. These findings suggest that KRAS/BRAF/PIK3CA and PTEN mutations are rare carcinogenic events in SMBTs. The high frequency of positive p53 staining and a low frequency of loss of ARID1A staining suggests that SMBT carcinogenesis may be related to the alteration of p53 rather than that of ARID1A. ERBB2 oncogenic mutations may play an important role in the tumorigenesis of Japanese SMBTs. Full article

Due to a prolonged period of quarantine during the COVID-19 pandemic, it is essential to monitor the physical condition of athletes isolated at home with a fitness tool that measures various aspects of physical fitness, which does not require any special equipment, and can be performed within a small space. This study assessed the reliability and validity of the test of performing the maximal number of burpees in 3 min (or 3-MBT) to monitor strength, power, and aerobic endurance in trained athletes. For Part I (reliability of the 3-MBT), 20 (10 male, 10 female) national athletes from various sports performed the 3-MBT on two separate test sessions. Athletes performed as many burpees as possible within 3 min and the primary performance criteria was the number of burpees completed (where a higher number reflected a better performance). The 3-MBT displayed excellent relative reliability in the athletes, with an intraclass correlation coefficient (ICC) and coefficient of variation (CV %) of >0.92, and <3.0%, respectively. For Part II (validity of the 3-MBT), 40 (20 M, 20 F) athletes performed the 3-MBT, and the countermovement jump (CMJ), isometric mid-thigh pull (IMTP), seated medicine ball throw (SMBT), isometric bench (IBP) and maximal aerobic power (VO_2max) tests on separate sessions. When data of male and female athletes were pooled, there were significant correlations between relative 3-MBT and relative CMJ height (r = 0.65, large; p < 0.001), relative IMPT peak force (r = 0.50, large; p < 0.001), relative IBP peak force (r = 0.36, moderate, p = 0.02), and relative VO_2max (r = 0.50, large; p < 0.001). In conclusion, the 3-MBT is a reliable and reasonably useful test and is a valid assessment of lower body power and strength, upper body strength and aerobic fitness in trained male and female athletes. Full article

This study aimed to examine the extent to which maturity offset, strength, and movement competency influences motor skill performance in adolescent boys. One hundred and eight secondary school boys completed anthropometric and physical testing on two non-consecutive days for the following variables: Maturity offset, isometric mid-thigh pull absolute (IMTP_ABS) and relative (IMTP_REL) peak force, resistance training skills quotient, 10-, 20-, and 30-m sprint time, countermovement jump height, horizontal jump distance, anaerobic endurance performance, and seated medicine ball throw (SMBT). The IMTP_REL displayed significant small to large correlations with all performance variables (r = 0.27–0.61), whereas maturity offset was significantly correlated with IMTP_ABS (r = 0.69), sprint (r = 0.29–0.33), jump (r = 0.23–0.34), and SMBT (r = 0.32). Absolute and relative strength were the strongest predictors of all performance variables and combined with maturity to explain 21%–76% of the variance. Low and average relative strength boys were nearly eight times (odds ratio: 7.80, confidence interval: 1.48–41.12, p < 0.05) and nearly four times (odds ratio: 3.86, confidence interval: 0.95–15.59, p < 0.05) more likely to be classified as lower competency compared to high relative strength boys. Relative strength has more influence on motor skill performance than maturity when compared with movement competency. Full article