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Keywords = Prodrug-amenable analogue.

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22 pages, 209 KiB  
Review
Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents
by Katalin Prokai-Tatrai and Laszlo Prokai
Molecules 2009, 14(2), 633-654; https://doi.org/10.3390/molecules14020633 - 6 Feb 2009
Cited by 19 | Viewed by 13461
Abstract
Prodrug design for brain delivery of small- and medium-sized neuropeptides was reviewed, focusing on thyrotropin-releasing hormone and structurally related peptides as examples. We have summarized our most important advances in methodology, as well as assessed the benefits and limitations of bioreversible chemical manipulation [...] Read more.
Prodrug design for brain delivery of small- and medium-sized neuropeptides was reviewed, focusing on thyrotropin-releasing hormone and structurally related peptides as examples. We have summarized our most important advances in methodology, as well as assessed the benefits and limitations of bioreversible chemical manipulation techniques to achieve targeting of the parent molecules into the central nervous system. The value of prodrug-amenable analogues as potential drug-like central nervous systems agents was highlighted. Full article
(This article belongs to the Special Issue Prodrugs)
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