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Keywords = Pituitary specific factor 1 (Pit-I)

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14 pages, 2630 KB  
Review
Challenging a “Cushy” Life: Potential Roles of Thermogenesis and Adipose Tissue Adaptations in Delayed Aging of Ames and Snell Dwarf Mice
by Teresa G. Valencak, Tanja Spenlingwimmer, Ricarda Nimphy, Isabel Reinisch, Jessica M. Hoffman and Andreas Prokesch
Metabolites 2020, 10(5), 176; https://doi.org/10.3390/metabo10050176 - 29 Apr 2020
Cited by 5 | Viewed by 4576
Abstract
Laboratory mouse models with genetically altered growth hormone (GH) signaling and subsequent endocrine disruptions, have longer lifespans than control littermates. As such, these mice are commonly examined to determine the role of the somatotropic axis as it relates to healthspan and longevity in [...] Read more.
Laboratory mouse models with genetically altered growth hormone (GH) signaling and subsequent endocrine disruptions, have longer lifespans than control littermates. As such, these mice are commonly examined to determine the role of the somatotropic axis as it relates to healthspan and longevity in mammals. The two most prominent mouse mutants in this context are the genetically dwarf Ames and Snell models which have been studied extensively for over two decades. However, it has only been proposed recently that both white and brown adipose tissue depots may contribute to their delayed aging. Here we review the current state of the field and supplement it with recent data from our labs. Full article
(This article belongs to the Special Issue Adipose Tissue and Metabolic Health)
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