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Keywords = Paratetilla sp.

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12 pages, 1844 KiB  
Communication
Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
by Qian Jia, Yuqi Du, Chen Wang, Yi Wang, Tonghan Zhu and Weiming Zhu
Mar. Drugs 2019, 17(5), 260; https://doi.org/10.3390/md17050260 - 30 Apr 2019
Cited by 31 | Viewed by 4401
Abstract
Four new azaphilones, sclerotiorins A–D (14), as well as the dimeric sclerotiorin E (5) of which we first determined its absolute configuration, and 12 known analogues (516) were isolated from the fermentation broth [...] Read more.
Four new azaphilones, sclerotiorins A–D (14), as well as the dimeric sclerotiorin E (5) of which we first determined its absolute configuration, and 12 known analogues (516) were isolated from the fermentation broth of Penicillium sclerotiorum OUCMDZ-3839 associated with a marine sponge Paratetilla sp.. The new structures, including absolute configurations, were elucidated by spectroscopic analyses, optical rotation, ECD spectra, X-ray single-crystal diffraction, and chemical transformations. Compounds 11 and 14 displayed significant inhibitory activity against α-glycosidase, with IC50 values of 17.3 and 166.1 μM, respectively. In addition, compounds 5, 7, 10, 1214, and 16 showed moderate bioactivity against H1N1 virus. Full article
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