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Keywords = N-triazolo-benzodiazepinones

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17 pages, 2034 KiB  
Article
Regioselective One-Pot Synthesis, Biological Activity and Molecular Docking Studies of Novel Conjugates N-(p-Aryltriazolyl)-1,5-benzodiazepin-2-ones as Potent Antibacterial and Antifungal Agents
by Asma Nsira, Hasan Mtiraoui, Sami Chniti, Hanan Al-Ghulikah, Rafik Gharbi and Moncef Msaddek
Molecules 2022, 27(13), 4015; https://doi.org/10.3390/molecules27134015 - 22 Jun 2022
Cited by 8 | Viewed by 2083
Abstract
Novel 1,2,3-triazolo-linked-1,5-benzodiazepinones were designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction (CuAAC). The chemical structures of these compounds were confirmed by 1H NMR, 13C NMR, HMBC, HRMS, and elemental analysis. The compounds were screened for their in vitro antibacterial [...] Read more.
Novel 1,2,3-triazolo-linked-1,5-benzodiazepinones were designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction (CuAAC). The chemical structures of these compounds were confirmed by 1H NMR, 13C NMR, HMBC, HRMS, and elemental analysis. The compounds were screened for their in vitro antibacterial and antifungal activities. Several compounds exhibited good to moderate activities compared to those of established standard drugs. Furthermore, the binding interactions of these active analogs were confirmed through molecular docking. Full article
(This article belongs to the Special Issue Click Chemistry in Organic Synthesis)
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