Search Results (6)

Many scholars believe that the Yi Jing 易經 (the Book of Changes) and traditional Chinese medicine share common mathematical principles, which are both predicated on the ontological of qi 氣 and the cosmological of correlative between nature and human. Traditional Chinese medicine emphasizes the systemic organization of organs, meridians, qi, and blood as central components by incorporating the mathematical principles, including the theory of “Chaos-Crack”, the infinite classification methods of yinyang 陰陽, the generative and restrictive interactions of wuxing 五行, and the metaphysical significance of special numbers such as one, two, three, etc. Traditional Chinese medicine also formulates many theories and methodologies by integrating these mathematical principles with the schemata of luoshu 洛書 and jiugong 九宮, as well as the special combination numbers such as tianliu diwu 天六地五. This research tries to explain the mathematical principles and applications from the body dimension in traditional Chinese medicine. Full article

As a national treasure, architectural heritage carries multiple value dimensions such as history, technology, art, and culture. With the increasing demand for architectural heritage protection and utilization, the traditional static digital model of architectural heritage based on geometric expression can no longer meet the practical application of multi-stage and multi-level scenarios. To this end, this paper proposes a value-chain-driven multi-level digital twin model of architectural heritage. Based on the three-stage logic of protection, management, and dissemination of value-chain classification, it integrates four types of models: geometry, physics, rules, and behavior. Combined with different hierarchical application levels, the digital model of architectural heritage is refined into a VCLOD (Value-Chain-Driven Level of Detail) detail hierarchy system to achieve a unified expression from spatial form restoration to intelligent response. Through the empirical application of three typical scenarios: the full-area guided tour of the Forbidden City, the exhibition curation of the central axis and the preventive protection of the Meridian Gate, the model shows the following specific results: (1) the efficiency of tourist guidance is improved through real-time personalized path planning; (2) the exhibition planning and visitor experience are improved through dynamic monitoring and interactive management of the exhibition environment; (3) the predictive analysis and preventive protection measures of structural safety are realized, effectively ensuring the structural safety of the Meridian Gate. The research results provide a theoretical basis and practical support for the systematic expression and intelligent evolution of digital twins of architectural heritage. Full article

Purpose: To investigate corneal densitometry artefacts found in Pentacam Scheimpflug scans and their potential effect on assessing keratoconic (KC) corneas compared to normal (N) corneas. Methods: The current study utilises Pentacam data of 458 N eyes, aged 35.6 ± 15.8 (range 10–87), referred to as the “N group”, and 314 KC eyes, aged 31.6 ± 10.8 (range 10–72), referred to as the “KC group”, where densitometry data were extracted and analysed via a custom-built MATLAB code. Radial summations of the densitometry were calculated at diameters ranging from 0.5 mm to 5.0 mm. The minimum normalised radial summation of densitometry (NRSD) value and angle were determined at each diameter and then linked. KC cone locations and areas of pathology were determined, and a comparison between N and KC groups was carried out both within the averaged area of pathology and over the corneal surface. Results: Joining minimum NRSD trajectory points marked a clear distortion line pointing to the nasal-superior direction at 65° from the nasal meridian. The findings were found to be independent of eye laterality or ocular condition. Consistency was detected in the right and left eyes among both the N and KC groups. The location of the KC cone centre and the area of pathology were determined, and the densitometry output was compared both within the area of pathology and over the whole cornea. When the average densitometry was compared between N and KC eyes within the KC area of pathology, the N group recorded a 16.37 ± 3.15 normalised grey-scale unit (NGSU), and the KC group recorded 17.74 ± 3.4 NGSU (p = 0.0001). However, when the whole cornea was considered, the N group recorded 16.71 ± 5.5 NGSU, and the KC group recorded 15.72 ± 3.98 NGSU (p = 0.0467). A weak correlation was found between the Bad D index and NGSU when the whole measured cornea was considered (R = −0.01); however, a better correlation was recorded within the KC area of pathology (R = 0.21). Conclusions: Nasal-superior artefacts are observed in the densitometry Pentacam maps, and analysis shows no significant differences in their appearance between N or KC corneas. When analysing KC corneas, it was found that the cone positions are mostly on the temporal-inferior side of the cornea, opposite to the densitometry artefact NRSD trajectory. The analysis suggests that the corneal densitometry artefacts do not interfere with the KC area of pathology as it reaches its extreme in the opposite direction; therefore, weighting the densitometry map to increase the contribution of the inferior-temporal cornea and decreasing that of the superior-nasal area would improve the classification or identification of KC if densitometry is to be used as a KC metric. Full article

All-sky airglow imagers (ASAIs) are used in the Meridian Project to observe the airglow in the middle and upper atmosphere to study the atmospheric perturbation. However, the ripples of airglow caused by the perturbation are only visible in the airglow images taken on a clear night. It is a problem to effectively select images suitable for scientific analysis from the enormous amount of airglow images captured under various environments due to the low efficiency and subjectivity of traditional manual classification. We trained a classification model based on convolutional neural network to distinguish between airglow images from clear nights and unclear nights. The data base contains 1688 images selected from the airglow images captured at Xinglong station (40.4° N, 30.5° E). The entire training process was tracked by feature maps which visualized every resulting classification model. The classification models with the clearest feature maps were saved for future use. We cropped the central part of the airglow images to avoid disturbance from the artificial lights at the edge of the vision field according to the feature maps of our first training. The accuracy of the saved model is 99%. The feature maps of five categories also indicate the reliability of the classification model. Full article

Natural products are the most important and commonly used in Traditional Chinese Medicine (TCM) for healthcare and disease prevention in East-Asia. Although the Meridian system of TCM was established several thousand years ago, the rationale of Meridian classification based on the ingredient compounds remains poorly understood. A core challenge for the traditional machine learning approaches for chemical activity prediction is to encode molecules into fixed length vectors but ignore the structural information of the chemical compound. Therefore, we apply a cost-sensitive graph convolutional neural network model to learn local and global topological features of chemical compounds, and discover the associations between TCM and their Meridians. In the experiments, we find that the performance of our approach with the area under the receiver operating characteristic curve (ROC-AUC) of 0.82 which is better than the traditional machine learning algorithm and also obtains 8%–13% improvement comparing with the state-of-the-art methods. We investigate the powerful ability of deep learning approach to learn the proper molecular descriptors for Meridian prediction and to provide novel insights into the complementary and alternative medicine of TCM. Full article

Plasmodium falciparum, Leishmania, Trypanosomes, are the causers of diseases such as malaria, leishmaniasis and African trypanosomiasis that nowadays are the most serious parasitic health problems worldwide. The great number of deaths and the few drugs available against these parasites, make necessary the search for new drugs. Some of these antiparasitic drugs also are GSK-3 inhibitors. GSKI-3 are candidates to develop drugs for the treatment of Alzheimer’s disease. In this work topological descriptors for a large series of 3,370 active/non-active compounds were initially calculated with the ModesLab software. Linear Discriminant Analysis was used to fit the classification function and it predicts heterogeneous series of compounds like paullones, indirubins, meridians, etc. This study thus provided a general evaluation of these types of molecules. Full article