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Article

9 Citations

2,361 Views

17 Pages

Homer1 Protects against Retinal Ganglion Cell Pyroptosis by Inhibiting Endoplasmic Reticulum Stress-Associated TXNIP/NLRP3 Inflammasome Activation after Middle Cerebral Artery Occlusion-Induced Retinal Ischemia

Weihao Lv,
Xiuquan Wu,
Yanan Dou,
Yiwen Yan,
Leiying Chen,
Zhou Fei and
Fei Fei

Int. J. Mol. Sci.2023, 24(23), 16811;https://doi.org/10.3390/ijms242316811

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27 November 2023

Retinal ischemia, after cerebral ischemia, is an easily overlooked pathophysiological problem in which inflammation is considered to play an important role. Pyroptosis is a kind of cell death pattern accompanied by inflammation. Homer scaffold protei...

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Article

23 Citations

3,803 Views

14 Pages

Hydrogen Sulfide Attenuates Neuroinflammation by Inhibiting the NLRP3/Caspase-1/GSDMD Pathway in Retina or Brain Neuron following Rat Ischemia/Reperfusion

Kun-Li Yang,
Wen-Hong Li,
Ya-Jie Liu,
Ying-Juan Wei,
Yan-Kai Ren,
Chen-Di Mai,
Si-Yu Zhang,
Yue Zuo,
Zhen-Zhou Sun and
Dong-Liang Li
+ 1 author

Brain Sci.2022, 12(9), 1245;https://doi.org/10.3390/brainsci12091245

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15 September 2022

Gasdermin D-executing pyroptosis mediated by NLRP3 inflammasomes has been recognized as a key pathogenesis during stroke. Hydrogen sulfide (H2S) could protect CNS against ischemia/reperfusion (I/R)-induced neuroinflammation, while the underlying mech...

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