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Keywords = Lemnalia bournei

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10 pages, 4593 KiB  
Article
New Diterpenes and Diterpene Glycosides with Antibacterial Activity from Soft Coral Lemnalia bournei
by Xiao Han, Huiting Wang, Bing Li, Xiaoyi Chen, Te Li, Xia Yan, Han Ouyang, Wenhan Lin and Shan He
Mar. Drugs 2024, 22(4), 157; https://doi.org/10.3390/md22040157 - 29 Mar 2024
Cited by 4 | Viewed by 2233
Abstract
Five new biflorane-type diterpenoids, biofloranates E–I (15), and two new bicyclic diterpene glycosides, lemnaboursides H–I (67), along with the known lemnabourside, were isolated from the South China Sea soft coral Lemnalia bournei. Their chemical [...] Read more.
Five new biflorane-type diterpenoids, biofloranates E–I (15), and two new bicyclic diterpene glycosides, lemnaboursides H–I (67), along with the known lemnabourside, were isolated from the South China Sea soft coral Lemnalia bournei. Their chemical structures and stereochemistry were determined based on extensive spectroscopic methods, including time-dependent density functional theory (TDDFT) ECD calculations, as well as a comparison of them with the reported values. The antibacterial activities of the isolated compounds were evaluated against five pathogenic bacteria, and all of these diterpenes and diterpene glycosides showed antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 4 to 64 µg/mL. In addition, these compounds did not exhibit noticeable cytotoxicities on A549, Hela, and HepG2 cancer cell lines, at 20 μM. Full article
(This article belongs to the Special Issue Bioactive Compounds from Soft Corals and Their Derived Microorganisms)
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11 pages, 797 KiB  
Article
Six New Diterpene Glycosides from the Soft Coral Lemnaliabournei
by Xia Yan, Han Ouyang, Te Li, Yutong Shi, Bin Wu, Xiaojun Yan and Shan He
Mar. Drugs 2021, 19(6), 339; https://doi.org/10.3390/md19060339 - 14 Jun 2021
Cited by 9 | Viewed by 3116
Abstract
A chemical study on the extracts of soft coral Lemnalia bournei resulted in the isolation and identification of six new bicyclic diterpene glycosides including three new lemnaboursides E–G (13), and three new lemnadiolboursides A–C (46), [...] Read more.
A chemical study on the extracts of soft coral Lemnalia bournei resulted in the isolation and identification of six new bicyclic diterpene glycosides including three new lemnaboursides E–G (13), and three new lemnadiolboursides A–C (46), along with three known lemnaboursides (79). Their structures were elucidated by detailed spectroscopic analysis, ECD analysis, chemical methods, and comparison with the literature data. Lemnadiolboursides A–C (46) contained a lemnal-1(10)-ene-7,12-diol moiety compared with the lemnaboursides. All these compounds were evaluated for antibacterial activity; cell growth inhibition of A549, Hela, HepG2, and CCRF-CEM cancer cell lines; and inhibition of LPS-induced NO production in RAW264.7 macrophages. The results indicated that compounds 1, 2, and 46 exhibited antibacterial activity against Staphylococcus aureus and Bacillus subtilis (MIC 4–16 μg/mL); compounds 19 displayed low cytotoxicity on the CCRF-CEM cell lines (IC50 10.44–27.40 µM); and compounds 1, 2, and 5 showed weak inhibition against LPS-induced NO production (IC50 21.56–28.06 μM). Full article
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