Search Results (4)

Innovation districts are widely known as an effective land use type for fostering and sustaining knowledge and innovation economy growth in cities. Knowledge workers and the public are among the main stakeholders and key drivers for the growth of innovation districts. However, these groups’ needs are often not well considered in the top-down implementation of innovation districts. This paper aims to explore the user preferences and decision makers’ perspectives in innovation district planning, design, and development. The study tackles the question of which characteristics fulfil the responsibility of innovation districts toward both societies (reflecting user preferences) and cities (reflecting decision makers’ perspectives). As for the methodology, a case study approach was employed to collect the required data from three innovation districts in Brisbane, Australia. The data are qualitatively and quantitatively analysed. The analysis findings highlighted the similarities between user preferences and decision makers’ perspectives—e.g., usefulness of decentralisation, urbanism, mixed-use development, street life, and social interactions in innovation districts—and the differences that need to be carefully factored into the planning, design, and development of innovation districts with a user-centric approach. Full article

As a new land use type, innovation districts are taking prominence in the urban development policies and plans of many cities across the globe. This new urban land use comes in many shapes and forms and offers various features and functions to the users. Despite its increasing popularity, there exist only limited approaches to classify innovation districts, and there are no holistic typologies developed so far. This study focuses on this understudied, but important area of research. The paper aims to develop an innovation district typology matrix and evaluates its practicality with real innovation district data. The methodological approach is three-fold. First, the multidimensional innovation district classification framework is adopted as a performance framework. Second, data from three eminent Australian innovation districts—i.e., Macquarie Park Innovation District (Sydney), Monash Technology Precinct (Melbourne), and Kelvin Grove Urban Village (Brisbane)—are collected. Third, both qualitative and quantitative analysis methods are employed for data analysis. The study finds that innovation district performances can be measured, and typologies can be developed though a novel approach. These, in return, inform property developers and managers, city administrators, and urban planners in their efforts to plan, design, develop, and manage competitive innovation districts. Full article

The era of knowledge-based urban development has led to an unprecedented increase in mobility of people and the subsequent growth in new typologies of agglomerated enclaves of knowledge such as knowledge and innovation spaces. Within this context, a new role has been assigned to contemporary public spaces to attract and retain the mobile knowledge workforce by creating a sense of place. This paper investigates place making in the globalized knowledge economy, which develops a sense of permanence spatio-temporally to knowledge workers displaying a set of particular characteristics and simultaneously is process-dependent getting developed by the internal and external flows and contributing substantially in the development of the broader context it stands in relation with. The paper reviews the literature and highlights observations from Kelvin Grove Urban Village, located in Australia’s new world city Brisbane, to understand the application of urban design as a vehicle to create and sustain place making in knowledge and innovation spaces. This research seeks to analyze the modified permeable typology of public spaces that makes knowledge and innovation spaces more viable and adaptive as per the changing needs of the contemporary globalized knowledge society. Full article

Haematopoietic stem cell (HSC) transplantation is an established cell-based therapy for a number of haematological diseases. To enhance this therapy, there is considerable interest in expanding HSCs in artificial niches prior to transplantation. This study compared murine HSC expansion supported through co-culture on monolayers of either undifferentiated mesenchymal stromal cells (MSCs) or osteoblasts. Sorted Lineage⁻ Sca-1⁺ c-kit⁺ (LSK) haematopoietic stem/progenitor cells (HPC) demonstrated proliferative capacity on both stromal monolayers with the greatest expansion of LSK shown in cultures supported by osteoblast monolayers. After transplantation, both types of bulk-expanded cultures were capable of engrafting and repopulating lethally irradiated primary and secondary murine recipients. LSKs co-cultured on MSCs showed comparable, but not superior, reconstitution ability to that of freshly isolated LSKs. Surprisingly, however, osteoblast co-cultured LSKs showed significantly poorer haematopoietic reconstitution compared to LSKs co-cultured on MSCs, likely due to a delay in short-term reconstitution. We demonstrated that stromal monolayers can be used to maintain, but not expand, functional HSCs without a need for additional haematopoietic growth factors. We also demonstrated that despite apparently superior in vitro performance, co-injection of bulk cultures of osteoblasts and LSKs in vivo was detrimental to recipient survival and should be avoided in translation to clinical practice. Full article