Search Results (2)

The two polar clinical forms of leprosy, termed tuberculoid and lepromatous, have polarized cellular immune responses with complex immunological distinctions. The predominance of DCs in tuberculoid leprosy has been reported, while the lepromatous pattern of illness is associated with weak activation of local populations of DCs. TiO₂ nanoparticles have previously been shown to induce maturation of these cells, leading to an inflammatory response similar to adjuvant usage in vaccine administration. We aimed to evaluate the effect of potassium-incorporated Ti oxide nanostructures, namely KTiO_xs, in the response of human monocyte-derived DCs to live M. leprae. Human monocytic cell line dual THP-1, which harbors two inducible reporter plasmid systems for transcription factor activation of NF-κB and interferon regulating factor (IRF), was treated with titanium control or with 1 mol/L KOH-treated Ti or 10 mol/L KOH for 24 h. Subsequently, cells were infected with M. leprae. KTiO_x nanoparticles increase DC phagocytic activity without inflammation. KTiO_x exposure of DCs led to an increase in IRF activation with modulation of the inflammatory response to live M. leprae. It also led to differential secretion of the critical components of innate immune response and the development of cell-mediated immunity against intracellular pathogens. This study demonstrates the effect of nanostructures of KTiO_xs and the usefulness of nanoparticle technology in the in vitro activation of human DCs against an infectious disease with a puzzling immune spectrum. Our findings may prompt future therapeutic strategies, such as DC immunotherapy for disseminated and progressive lepromatous lesions. Full article

Generally, nanoparticles (NPs) are used as photocatalysts, which sometimes results in difficulties in the separation and recycling of photocatalysts from suspensions after their application in water and wastewater treatment, which hinders industrial applications of NPs that are too fine to be removed by gravitational settling. This can be solved by using support NPs to overcome these problems. -OH enrich AlO(OH), which is produced by a steam coating process, has been could be used as a possible support, because the -OH groups on the surface can interact with foreign molecules; thus, various composite functional materials can be prepared. Potassium doped titanium oxide NPs, which are produced by a wet corrosion process, namely KTiO_xs, have been selected as photocatalysts, because KTiO_xs have sufficient K⁺ ions, thereby expecting the chemical bonding with -OH group from AlO(OH). This study fabricated a novel photocataysis system made by combining KTiO_xs as catalysts and AlO(OH) as the catalysts’ support, namely KTiO_xs/AlO(OH) composites. The KTiO_xs nanowires, obtained from 10 mol/L of a KOH solution treated with Ti and AlO(OH) at 280 °C for 24 h through a steam coating process, yielded the highest surface area and the highest photocatalytic performance. Full article