Search Results (4)

Political religion is a concept that gained prominence around the middle of the twentieth century, being associated for many with the idea of a totalitarian regime. Political religion was seen as a secular ideology whose followers took it up with the enthusiasm and commitment normally associated with adherence to religion. Comprising liturgy, ritual and the sacralization of politics, it created a community of believers, and usually had a transcendental leadership and a millennial vision of a promised future. This paper will explore the utility of this concept for understanding leader cults in authoritarian regimes. Such cults have been prominent features of authoritarian regimes but there is little agreement at the conceptual level about how they should be understood. One of the most powerful of such cults was that of Joseph Stalin in the Soviet Union from 1929 to 1953. This paper analyses this cult in terms of liturgy and ritual and concludes that despite some aspects that are common between the cult and religion, most ritualistic aspects of religion find no direct counterpart in the cult. Full article

Recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV)-1 and -2 initiate virus infection by binding of their spike glycoprotein with the cell-surface receptor angiotensin-converting enzyme 2 (ACE2) and enter into the host cells mainly via the clathrin-mediated endocytosis pathway. However, the internalization process post attachment with the receptor is not clear for both SARS-CoV-1 and -2. Understanding the cellular factor/s or pathways used by these CoVs for internalization might provide insights into viral pathogenesis, transmission, and development of novel therapeutics. Here, we demonstrated that the cytoplasmic tail of ACE2 is not essential for the entry of SARS-CoV-1 and -2 by using bioinformatics, mutational, confocal imaging, and pseudotyped SARS-CoVs infection studies. ACE2 cytoplasmic domain (cytACE2) contains a conserved internalization motif and eight putative phosphorylation sites. Complete cytoplasmic domain deleted ACE2 (∆cytACE2) was properly synthesized and presented on the surface of HEK293T and BHK21 cells like wtACE2. The SARS-CoVs S1 or RBD of spike protein binds and colocalizes with the receptors followed by internalization into the host cells. Moreover, pseudotyped SARS-CoVs entered into wtACE2- and ∆cytACE2-transfected cells but not into dipeptidyl peptidase 4 (DPP4)-expressing cells. Their entry was significantly inhibited by treatment with dynasore, a dynamin inhibitor, and NH₄Cl, an endosomal acidification inhibitor. Furthermore, SARS-CoV antibodies and the soluble form of ACE2-treated pseudotyped SARS-CoVs were unable to enter the wtACE2 and ∆cytACE2-expressing cells. Altogether, our data show that ACE2 cytoplasmic domain signaling is not essential for the entry of SARS-CoV-1 and -2 and that SARS-CoVs entry might be mediated via known/unknown host factor/s. Full article

In this work, the experimental investigations were piloted to study the influence of hybrid nanoparticles containing SiO₂ and CeO₂ nanoparticles on thermo-physical characteristics of the paraffin-based phase change material (PCM). Initially, the hybrid nanoparticles were prepared by blending equal mass of SiO₂ and CeO₂ nanoparticles. The hybrid-nano/paraffin (HnP) samples were prepared by cautiously dispersing 0, 0.5, 1.0, and 2.0 percentage mass of hybrid nanoparticles inside the paraffin, respectively. The synthesized samples were examined under different instruments such as field emission scanning electron microscope (FESEM), Fourier transform infrared spectrometer (FTIR), differential scanning calorimetry (DSC), thermogravimetric analyzer (TGA), and thermal properties analyzer to ascertain the influence of hybrid nanoparticles on thermo-physical characteristics of the prepared samples. The obtained experimental results proved that the hybrid nanoparticles were uniformly diffused in the paraffin matrix without affecting the chemical arrangement of paraffin molecules. Prominently, the relative thermal stability and relative thermal conductivity of the paraffin were synergistically enriched up to 115.49% and 165.56%, respectively, when dispersing hybrid nanoparticles within paraffin. Furthermore, the hybrid nanoparticles appropriately amended the melting and crystallization point of the paraffin to reduce its supercooling, and the maximum reduction in supercooling was ascertained as 35.81%. The comprehensive studies indicated that the paraffin diffused with SiO₂ and CeO₂ hybrid nanoparticles at 1.0 mass percentage would yield a better outcome compared to the next higher mass fractions without much diminishing the latent heat of paraffin. Hence, it is recommended to utilize the hybrid-nano/paraffin with 1.0 mass fraction of the aforementioned hybrid nanoparticles for effectively augmenting the thermal energy capacity of low-temperature solar thermal systems. Full article