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Keywords = Heptaptera anatolica

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8 pages, 1308 KiB  
Article
Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica
by Fatma Tosun, John A. Beutler, Tanya T. Ransom and Mahmut Miski
Molecules 2019, 24(6), 1153; https://doi.org/10.3390/molecules24061153 - 23 Mar 2019
Cited by 31 | Viewed by 3987
Abstract
Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins [...] Read more.
Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (8) and 14′-acetoxybadrakemin (7) were observed at nanomolar level against the UO31 kidney cancer cell line. Full article
(This article belongs to the Collection Natural Products: Anticancer Potential and Beyond)
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