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Keywords = DenBalo

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12 pages, 1236 KiB  
Article
Comparison of Gestational Age Assessment Methods in the Second and Third Trimesters: Evaluating Alternative Approaches Against Ultrasound in Urban Burkina Faso
by Cheick Ahmed Ouattara, Anderson Compaoré, Lionel Olivier Ouédraogo, Moctar Ouédraogo, Hermann Ouattara, Moussa Coulibaly, Lishi Deng, Zakari Nikiéma, Giles T. Hanley-Cook, Alemayehu Argaw, Lieven Huybregts, Kokeb Tesfamariam Hadush, Carl Lachat, Laeticia Celine Toe and Trenton Dailey-Chwalibóg
J. Clin. Med. 2025, 14(5), 1421; https://doi.org/10.3390/jcm14051421 - 20 Feb 2025
Cited by 1 | Viewed by 1377
Abstract
Background: Accurate determination of gestational age by way of ultrasound is challenging in resource-limited settings like Burkina Faso, leading to the use of alternative methods, though their accuracy and agreement remain poorly established. This practice leads to inadequate risk assessment during pregnancy [...] Read more.
Background: Accurate determination of gestational age by way of ultrasound is challenging in resource-limited settings like Burkina Faso, leading to the use of alternative methods, though their accuracy and agreement remain poorly established. This practice leads to inadequate risk assessment during pregnancy and failure to identify preterm birth, potentially contributing to high neonatal mortality rates. The purpose of this study was to determine the agreement among alternative methods for gestational age estimation and the Alliance for Maternal and Newborn Health Improvement (AMANHI) method in Burkina Faso. Methods: Data were obtained from a prospective cohort study involving pregnant women in the second or third trimester in Bobo-Dioulasso to evaluate the agreement of last menstrual period (LMP), symphysis-fundal height (SFH), Dubowitz, Hadlock, and AMAHNI methods to estimate gestational age. The degree of agreement was assessed using the Bland–Altman method and intraclass correlation coefficients. The AMANHI method, validated for late pregnancy, was used as the reference standard. Results: A total of 768 pregnant women were included in the analysis. Plots showed a lack of agreement between the AMANHI method and all other methods, with 95% limits of agreement ranging from −7.6 to +9.8 weeks. Additionally, the incidence of preterm birth was consistently higher when assessed using the alternative methods compared with the AMANHI method. Conclusions: The clinical methods (SFH, LMP, Dubowitz) disagree with the ultrasound methods (AMANHI, Hadlock), but the ultrasound methods produce more similar results. The routine application of other methods is likely to result in an overestimation of preterm birth incidence compared with AMANHI. These findings highlight the urgent need to improve access to obstetric ultrasound and to provide comprehensive training in the application of the AMANHI method for accurate late-term gestational age estimation in Burkina Faso. Full article
(This article belongs to the Section Obstetrics & Gynecology)
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15 pages, 524 KiB  
Study Protocol
Describing Biological Vulnerability in Small, Vulnerable Newborns in Urban Burkina Faso (DenBalo): Gut Microbiota, Immune System, and Breastmilk Assembly
by Lionel Olivier Ouédraogo, Lishi Deng, Cheick Ahmed Ouattara, Anderson Compaoré, Moctar Ouédraogo, Alemayehu Argaw, Carl Lachat, Eric R. Houpt, Queen Saidi, Filomeen Haerynck, Justin Sonnenburg, Meghan B. Azad, Simon J. Tavernier, Yuri Bastos-Moreira, Laeticia Celine Toe and Trenton Dailey-Chwalibóg
Nutrients 2024, 16(23), 4242; https://doi.org/10.3390/nu16234242 - 9 Dec 2024
Cited by 2 | Viewed by 1717
Abstract
Background: Small vulnerable newborns (SVNs), including those born preterm, small for gestational age, or with low birth weight, are at higher risk of neonatal mortality and long-term health complications. Early exposure to maternal vaginal microbiota and breastfeeding plays a critical role in [...] Read more.
Background: Small vulnerable newborns (SVNs), including those born preterm, small for gestational age, or with low birth weight, are at higher risk of neonatal mortality and long-term health complications. Early exposure to maternal vaginal microbiota and breastfeeding plays a critical role in the development of the neonatal microbiota and immune system, especially in low-resource settings like Burkina Faso, where neonatal mortality rates remain high. Objectives: The DenBalo study aims to investigate the role of maternal and neonatal factors, such as vaginal and gut microbiota, immune development, and early nutrition, in shaping health outcomes in SVNs and healthy infants. Methods: This prospective cohort observational study will recruit 141 mother-infant pairs (70 SVNs and 71 healthy controls) from four health centers in Bobo-Dioulasso, Burkina Faso. The mother-infant pairs will be followed for six months with anthropometric measurements and biospecimen collections, including blood, breast milk, saliva, stool, vaginal swabs, and placental biopsies. Multi-omics approaches, encompassing metagenomics, metabolomics, proteomics, and immune profiling, will be used to assess vaginal and gut microbiota composition and functionality, immune cell maturation, and cytokine levels at critical developmental stages. Conclusions: This study will generate comprehensive data on how microbiota, metabolomic, and proteomic profiles, along with immune system development, differ between SVNs and healthy infants. These findings will guide targeted interventions to improve neonatal health outcomes and reduce mortality, particularly in vulnerable populations. Full article
(This article belongs to the Section Pediatric Nutrition)
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