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3 Results Found

  • Article
  • Open Access
4 Citations
2,790 Views
15 Pages

Identification of Furin Protease Small-Molecule Inhibitor with a 1,3-Thiazol-2-ylaminosulfonyl Scaffold

  • Anja Kolarič,
  • Vid Ravnik,
  • Sara Štumpf Horvat,
  • Marko Jukič and
  • Urban Bren

19 February 2025

Background: Proteolytic cleavage of inactive pathogen proteins by furin is critical for their entry into human cells, and thus furin cleavage of the SARS-CoV-2 spike protein was identified as a prerequisite for virus binding and the subsequent infect...

(This article belongs to the Section Medicinal Chemistry)
  • Review
  • Open Access
8 Citations
2,001 Views
40 Pages

Neglected Disease – African Sleeping Sickness: Recent Synthetic and Modeling Advances

  • Sarvesh K. PALIWAL,
  • Ankita Narayan VERMA and
  • Shailendra PALIWAL

10 May 2011

Human African Trypanosomiasis (HAT) also called sleeping sickness is caused by subspecies of the parasitic hemoflagellate Trypanosoma brucei that mostly occurs in sub-Saharan Africa. The current chemotherapy of the human trypanosomiases relies on onl...

  • Article
  • Open Access
30 Citations
6,084 Views
14 Pages

Investigating the Antimicrobial Properties of Essential Oil Constituents and Their Mode of Action

  • Ilham Noui Mehidi,
  • Abdenour Ait Ouazzou,
  • Wafa Tachoua and
  • Karim Hosni

30 August 2024

Essential oils (EOs) and plant extracts, rich in beneficial chemical compounds, have diverse applications in medicine, food, cosmetics, and agriculture. This study investigates the antibacterial activity of nine essential oil constituents (EOCs) agai...

(This article belongs to the Section Natural Products Chemistry)