Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = Chlamydia abortus 1B vaccine strain

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
15 pages, 3745 KB  
Article
Distribution and Severity of Placental Lesions Caused by the Chlamydia abortus 1B Vaccine Strain in Vaccinated Ewes
by Sergio Gastón Caspe, Javier Palarea-Albaladejo, Clare Underwood, Morag Livingstone, Sean Ranjan Wattegedera, Elspeth Milne, Neil Donald Sargison, Francesca Chianini and David Longbottom
Pathogens 2021, 10(5), 543; https://doi.org/10.3390/pathogens10050543 - 30 Apr 2021
Cited by 7 | Viewed by 3129
Abstract
Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease [...] Read more.
Chlamydia abortus infects livestock species worldwide and is the cause of enzootic abortion of ewes (EAE). In Europe, control of the disease is achieved using a live vaccine based on C. abortus 1B strain. Although the vaccine has been useful for controlling disease outbreaks, abortion events due to the vaccine have been reported. Recently, placental pathology resulting from a vaccine type strain (vt) infection has been reported and shown to be similar to that resulting from a natural wild-type (wt) infection. The aim of this study was to extend these observations by comparing the distribution and severity of the lesions, the composition of the predominating cell infiltrate, the amount of bacteria present and the role of the blood supply in infection. A novel system for grading the histological and pathological features present was developed and the resulting multi-parameter data were statistically transformed for exploration and visualisation through a tailored principal component analysis (PCA) to evaluate the difference between them. The analysis provided no evidence of meaningful differences between vt and wt strains in terms of the measured pathological parameters. The study also contributes a novel methodology for analysing the progression of infection in the placenta for other abortifacient pathogens. Full article
(This article belongs to the Special Issue Transmissible Diseases Affecting Reproduction in Small Ruminants)
Show Figures

Figure 1

Back to TopTop