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Keywords = Chaetomium globosum kz-19

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Article
New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19
by Tantan Li, Yun Wang, Li Li, Mengyue Tang, Qinghong Meng, Cun Zhang, Erbing Hua, Yuehu Pei and Yi Sun
Mar. Drugs 2021, 19(8), 438; https://doi.org/10.3390/md19080438 - 31 Jul 2021
Cited by 14 | Viewed by 2957
Abstract
Four new cytochalasans, phychaetoglobins A–D (14), together with twelve known cytochalasans (516), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, [...] Read more.
Four new cytochalasans, phychaetoglobins A–D (14), together with twelve known cytochalasans (516), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established by application of Mosher’s method. Compounds 48 exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC50 values less than 20 μM. Full article
(This article belongs to the Special Issue Bioactive Compounds from Marine Angiosperms)
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