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Keywords = Cephalosporium sp.AL031 fungus

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6 pages, 198 KiB  
Article
A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031
by Xiang-Zhong Huang, Yun Zhu, Xiao-Li Guan, Kai Tian, Jun-Ming Guo, Hong-Bin Wang and Guang-Miao Fu
Molecules 2012, 17(4), 4219-4224; https://doi.org/10.3390/molecules17044219 - 5 Apr 2012
Cited by 33 | Viewed by 7855
Abstract
Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4 [...] Read more.
Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 14 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay. Full article
(This article belongs to the Section Medicinal Chemistry)
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