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Keywords = Cantabrian Sea-derived actinobacteria

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9 pages, 1002 KiB  
Article
Paulomycin G, a New Natural Product with Cytotoxic Activity against Tumor Cell Lines Produced by Deep-Sea Sediment Derived Micromonospora matsumotoense M-412 from the Avilés Canyon in the Cantabrian Sea
by Aida Sarmiento-Vizcaíno, Alfredo F. Braña, Ignacio Pérez-Victoria, Jesús Martín, Nuria De Pedro, Mercedes De la Cruz, Caridad Díaz, Francisca Vicente, José L. Acuña, Fernando Reyes, Luis A. García and Gloria Blanco
Mar. Drugs 2017, 15(9), 271; https://doi.org/10.3390/md15090271 - 28 Aug 2017
Cited by 48 | Viewed by 6877
Abstract
The present article describes a structurally novel natural product of the paulomycin family, designated as paulomycin G (1), obtained from the marine strain Micromonospora matsumotoense M-412, isolated from Cantabrian Sea sediments collected at 2000 m depth during an oceanographic expedition to [...] Read more.
The present article describes a structurally novel natural product of the paulomycin family, designated as paulomycin G (1), obtained from the marine strain Micromonospora matsumotoense M-412, isolated from Cantabrian Sea sediments collected at 2000 m depth during an oceanographic expedition to the submarine Avilés Canyon. Paulomycin G is structurally unique since—to our knowledge—it is the first member of the paulomycin family of antibiotics lacking the paulomycose moiety. It is also the smallest bioactive paulomycin reported. Its structure was determined using HRMS and 1D and 2D NMR spectroscopy. This novel natural product displays strong cytotoxic activities against different human tumour cell lines, such as pancreatic adenocarcinoma (MiaPaca_2), breast adenocarcinoma (MCF-7), and hepatocellular carcinoma (HepG2). The compound did not show any significant bioactivity when tested against a panel of bacterial and fungal pathogens. Full article
(This article belongs to the Collection Marine Compounds and Cancer)
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8 pages, 716 KiB  
Article
Lobophorin K, a New Natural Product with Cytotoxic Activity Produced by Streptomyces sp. M-207 Associated with the Deep-Sea Coral Lophelia pertusa
by Alfredo F. Braña, Aida Sarmiento-Vizcaíno, Miguel Osset, Ignacio Pérez-Victoria, Jesús Martín, Nuria De Pedro, Mercedes De la Cruz, Caridad Díaz, Francisca Vicente, Fernando Reyes, Luis A. García and Gloria Blanco
Mar. Drugs 2017, 15(5), 144; https://doi.org/10.3390/md15050144 - 19 May 2017
Cited by 61 | Viewed by 8533
Abstract
The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m [...] Read more.
The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus. Full article
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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