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Keywords = Aldisa andersoni

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13 pages, 515 KiB  
Article
Chemistry of the Nudibranch Aldisa andersoni: Structure and Biological Activity of Phorbazole Metabolites
by Genoveffa Nuzzo, Maria Letizia Ciavatta, Robert Kiss, Véronique Mathieu, Helene Leclercqz, Emiliano Manzo, Guido Villani, Ernesto Mollo, Florence Lefranc, Lisette D’Souza, Margherita Gavagnin and Guido Cimino
Mar. Drugs 2012, 10(8), 1799-1811; https://doi.org/10.3390/md10081799 - 20 Aug 2012
Cited by 27 | Viewed by 8867
Abstract
The first chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been [...] Read more.
The first chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out. Full article
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