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Keywords = 5-butylpicolinic acid

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10 pages, 927 KiB  
Communication
Concise Total Synthesis and Antifungal Activities of Fusaric Acid, a Natural Product
by Bin Bin Huang, Ya Yi Liu, Peng Fei Zhu, Yi Cheng Jiang and Ming-An Ouyang
Molecules 2020, 25(17), 3859; https://doi.org/10.3390/molecules25173859 - 25 Aug 2020
Cited by 9 | Viewed by 4451
Abstract
The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as [...] Read more.
The total synthesis of a natural product alkaloid fusaric acid (FA), which exhibits herbicide, fungicide, insecticide and even diverse notable pharmacological activities, was accomplished in four steps using commercially available materials. The synthesis, based on a unified and flexible strategy using 6-bromonicotinaldehyde as a common intermediate, is concise, convergent, practical and can be carried out on a two-gram scale. This approach could be readily applicable to the synthesis of its analogues. In addition, FA had a wide range of inhibitory activities against 14 plant pathogenic fungi in this study, which demonstrated that as a leading compound, and it has great potential to be further developed as an agricultural fungicide. Full article
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