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Keywords = 4-chloro-5-sulfamoylanthranilyc acid

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13 pages, 4451 KB  
Article
An Insight into the Degradation Processes of the Anti-Hypertensive Drug Furosemide
by Micaela Giannetti, Viviana Claudia Canale, Laura Micheli, Maurizio Fiori, Claudia Mazzuca and Antonio Palleschi
Molecules 2023, 28(1), 381; https://doi.org/10.3390/molecules28010381 - 2 Jan 2023
Cited by 4 | Viewed by 4361
Abstract
Furosemide (FUR), an active pharmaceutical ingredient (API) belonging to a group of drugs known as loop diuretics, has widespread use, but, is characterized by a strong instability to light, which causes chemical transformations that could give a yellowing phenomenon and have a significant [...] Read more.
Furosemide (FUR), an active pharmaceutical ingredient (API) belonging to a group of drugs known as loop diuretics, has widespread use, but, is characterized by a strong instability to light, which causes chemical transformations that could give a yellowing phenomenon and have a significant impact from a health and marketing point of view. Many studies have tried to explain this phenomenon under different experimental conditions, but no detailed explanation of the yellowing phenomenon has been provided. This work, unlike the others, provides an overall view and explanation of the behavior of FUR in relation to the yellowing phenomenon, both in the solution and in solid state, considering several aspects, such as light exposure, presence of oxygen, and moisture effects. Full article
(This article belongs to the Special Issue Chemical Analysis of Bioactive Compounds)
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