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Keywords = 2-Aminobenzoxazoles

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6 pages, 1052 KB  
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N-(Benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)amino)butanamide
by Hugo Pilotzi-Xahuentitla, Gabriela del Carmen Canche-Naal, Rolffy Ruben Ortiz-Andrade, Gabriel Navarrete-Vázquez and Emanuel Hernández-Núñez
Molbank 2024, 2024(3), M1854; https://doi.org/10.3390/M1854 - 23 Jul 2024
Viewed by 2514
Abstract
Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N-(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained [...] Read more.
Benzazoles, such as benzoxazoles and benzothiazoles, are compounds with important biological and pharmacological activities and important intermediaries in synthesis. This report presents the synthesis of a butanamide derived from linking 5-chloro-2-aminobenzoxazole and 2-aminobenzothiazole via 4-chlorobutanoyl chloride. The corresponding compound N-(benzothiazol-2-yl)-4-((5-chlorobenzoxazol-2-yl)aminobutanamide was obtained at a 76% global yield using accessible starting materials and a methodology in two reaction steps. Furthermore, we conducted docking studies of this compound on 3-TOP protein to explore its potential as an antidiabetic agent. Full article
(This article belongs to the Collection Molecules from Side Reactions)
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9 pages, 1462 KB  
Article
The Synthesis of 2-Aminobenzoxazoles Using Reusable Ionic Liquid as a Green Catalyst under Mild Conditions
by Ya Zhou, Zhiqing Liu, Tingting Yuan, Jianbin Huang and Chenjiang Liu
Molecules 2017, 22(4), 576; https://doi.org/10.3390/molecules22040576 - 2 Apr 2017
Cited by 11 | Viewed by 7798
Abstract
A facile, green, and efficient method for the direct oxidative amination of benzoxazoles using heterocyclic ionic liquid as catalyst has been developed. The reaction proceeded smoothly at room temperature and gave the desirable 2-aminobenzoxazoles with good to excellent yields (up to 97%). The [...] Read more.
A facile, green, and efficient method for the direct oxidative amination of benzoxazoles using heterocyclic ionic liquid as catalyst has been developed. The reaction proceeded smoothly at room temperature and gave the desirable 2-aminobenzoxazoles with good to excellent yields (up to 97%). The catalyst 1-butylpyridinium iodide can be easily recycled and reused with similar efficacies for at least four cycles. Full article
(This article belongs to the Section Green Chemistry)
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