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Keywords = 2’,4’-dihydroxydihydrochalcone

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8 pages, 847 KiB  
Communication
Synthesis and Anti-Saprolegnia Activity of New 2’,4’-Dihydroxydihydrochalcone Derivatives
by Enrique Werner, Iván Montenegro, Bastian Said, Patricio Godoy, Ximena Besoain, Nelson Caro and Alejandro Madrid
Antibiotics 2020, 9(6), 317; https://doi.org/10.3390/antibiotics9060317 - 10 Jun 2020
Cited by 5 | Viewed by 3102
Abstract
In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 39) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, [...] Read more.
In the present study, seven 2’,4’-dihydroxydihydrochalcone derivatives (compounds 39) were synthesized and their capacity as anti-Saprolegnia agents were evaluated against Saprolegnia parasitica, S. australis, S. diclina. Derivative 9 showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100–175 μg/mL and 100–200 μg/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound 9 caused damage and disintegration cell membrane of all Saprolegnia strains over the action of commercial controls. Full article
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