A series of quinoxaline derivatives has been synthesized by reacting 3-hydrazinoquinoxalines
1a,b with many bifunctional reagents. Reaction of
1a,b with chloroacetyl chloride and ethyl chloroacetate afforded 1-chloromethyl[1,2,4]tnazoIo[4,3-a]quinoxalines
2a,b and dihydro[1,2,4]triazino[4,3-a]quinoxalin-2-ones
3a,b respectively. Condensation of
1a,b with ethyl acetoacetate and acetylacetone yielded 2-quinoxalinylhydrazonobutanoates
4a,b
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A series of quinoxaline derivatives has been synthesized by reacting 3-hydrazinoquinoxalines
1a,b with many bifunctional reagents. Reaction of
1a,b with chloroacetyl chloride and ethyl chloroacetate afforded 1-chloromethyl[1,2,4]tnazoIo[4,3-a]quinoxalines
2a,b and dihydro[1,2,4]triazino[4,3-a]quinoxalin-2-ones
3a,b respectively. Condensation of
1a,b with ethyl acetoacetate and acetylacetone yielded 2-quinoxalinylhydrazonobutanoates
4a,b and 2-quinoxalinylhydrazono-2-pentanones
5a,b respectively. Cyclization of
5a,b gave 3,5-dimethylpyrazolylquinoxalines
6a,b. Moreover, reaction of compounds
2a,b with N-phenyl piperazine derivatives afforded 4-(4-Arylpiperazin-1-yl)-1-[(4-arylpiperazin-1-yl) methyl)]triazoloquinoxalines
7a−e. The prepared compounds were screened for
in vitro antibacterial and antifungal activities. None of the tested compounds showed significant activity towards
Pseudomonas aeruginosa. However, remarkable activities were noticed for compounds
5a and
5b against
Eschenchia coli.
Staphylococcus aureus and
Candida albicans. Compounds
6a and
6b lacked any antimicrobial activities against the tested microorganisms.
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