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Keywords = α-ketoacetals

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15 pages, 270 KiB  
Article
Efficient Preparation of α-Ketoacetals
by Francisco Ayala-Mata, Citlalli Barrera-Mendoza, Hugo A. Jiménez-Vázquez, Elena Vargas-Díaz and L. Gerardo Zepeda
Molecules 2012, 17(12), 13864-13878; https://doi.org/10.3390/molecules171213864 - 22 Nov 2012
Cited by 13 | Viewed by 13011
Abstract
The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3aj in 70–99% yield. These compounds represent a versatile arrangement [...] Read more.
The Weinreb amides 2a,b were prepared from the α,α-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α-ketoacetals 3aj in 70–99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol. Full article
(This article belongs to the Section Organic Chemistry)
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