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18 pages, 872 KiB

Open AccessArticle

Hyperbolic Scenario of Accelerating Universe in Modified Gravity

by Raja Azhar Ashraaf Khan, Rishi Kumar Tiwari, Jumi Bharali, Amine Bouali, G. Dilara Açan Yildiz and Ertan Güdekli

Symmetry 2023, 15(6), 1238; https://doi.org/10.3390/sym15061238 - 9 Jun 2023

Cited by 2 | Viewed by 1631

Abstract

Throughout this study, locally rotationally symmetric (LRS) Bianchi type-V space-time is pondered with Tsallis holographic dark energy (THDE) with the Granda–Oliveros (GO) cut-off in the Sáez–Ballester (SB) theory of gravity. A parameterization of the deceleration parameter

(q)

has been suggested: [...] Read more.

(q)

has been suggested:

q = α - \frac{β}{H^{2}}

. The proposed deceleration parameterization demonstrates the Universe’s phase transition from early deceleration to current acceleration. Markov chain Monte Carlo (MCMC) was utilized to have the best-fit value for our model parameter and confirm that the model satisfies the recent observational data. Additional parameters such as deceleration parameter q with cosmographic parameters jerk, snap, and lerk have also been observed physically and graphically. The constructed model is differentiated from other dark energy models using statefinder pair analysis. Some important features of the model are discussed physically and geometrically. Full article

(This article belongs to the Special Issue Application of Symmetry in Gravity Researches)

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13 pages, 2473 KiB

Open AccessFeature PaperArticle

The α6 GABA_A Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome

by Roberto Cadeddu, Daniel E. Knutson, Laura J. Mosher, Stefanos Loizou, Karen Odeh, Janet L. Fisher, James M. Cook and Marco Bortolato

Biomolecules 2021, 11(2), 175; https://doi.org/10.3390/biom11020175 - 28 Jan 2021

Cited by 17 | Viewed by 3689

Abstract

Tourette syndrome (TS) is a disabling neurodevelopmental disorder characterized by multiple, recurrent tics. The pharmacological treatment of TS is currently based on dopaminergic antagonists; however, these drugs are associated with extrapyramidal symptoms and other serious adverse events. Recent evidence suggests that positive allosteric modulators (PAMs) of GABA_A receptors containing α6 subunits (α6 GABA_ARs) oppose the behavioral effects of dopamine. Building on this evidence, in the present study, we tested the efficacy of DK-I-56-1, a highly selective PAM for α6 GABA_ARs, in mouse models of TS exhibiting tic-related responses. DK-I-56-1 significantly reduced tic-like jerks and prepulse inhibition (PPI) deficits in D1CT-7 transgenic mice, a well-documented mouse model of TS. DK-I-56-1 also prevented the exacerbation of spontaneous eyeblink reflex induced by the potent dopamine D₁ receptor agonist SKF 82958, a proxy for tic-like responses. We also showed that both systemic and prefrontal cortical administration of DK-I-56-1 countered the PPI disruption caused by SKF 82958. Although the effects of DK-I-56-1 were akin to those elicited by dopaminergic antagonists, this drug did not elicit extrapyramidal effects, as measured by catalepsy. These results point to α6 GABA_AR PAMs as promising TS therapies with a better safety profile than dopaminergic antagonists. Full article

(This article belongs to the Special Issue Drug Design and Development for Diagnosis and Treatment of Neuropsychiatric Diseases)

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25 pages, 1847 KiB

Open AccessArticle

Maximum Correntropy Criterion Kalman Filter for α-Jerk Tracking Model with Non-Gaussian Noise

by Bowen Hou, Zhangming He, Xuanying Zhou, Haiyin Zhou, Dong Li and Jiongqi Wang

Entropy 2017, 19(12), 648; https://doi.org/10.3390/e19120648 - 29 Nov 2017

Cited by 40 | Viewed by 6617

Abstract

As one of the most critical issues for target track,

α

-jerk model is an effective maneuver target track model. Non-Gaussian noises always exist in the track process, which usually lead to inconsistency and divergence of the track filter. A novel Kalman filter [...] Read more.

As one of the most critical issues for target track,

α

α

-jerk tracking model to handle non-Gaussian noise. The weighted least square solution is presented and the standard Kalman filter is deduced firstly. A novel Kalman filter with the weighted least square based on the maximum correntropy criterion is deduced. The robustness of the maximum correntropy criterion is also analyzed with the influence function and compared with the Huber-based filter, and, moreover, the kernel size of Gaussian kernel plays an important role in the filter algorithm. A new adaptive kernel method is proposed in this paper to adjust the parameter in real time. Finally, simulation results indicate the validity and the efficiency of the proposed filter. The comparison study shows that the proposed filter can significantly reduce the noise influence for

α

-jerk model. Full article

(This article belongs to the Special Issue Entropy in Signal Analysis)

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