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Keywords = therapeutic vaccine
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16 pages, 327 KB  
Review
Peptide Vaccine Therapy in Colorectal Cancer
by Aleksandra Bartnik, Ajit Johnson Nirmal and Shi-Yu Yang
Vaccines 2013, 1(1), 1-16; https://doi.org/10.3390/vaccines1010001 - 24 Aug 2012
Cited by 23 | Viewed by 16097
Abstract
Colorectal cancer is the third most common cause of cancer-related deaths and the second most prevalent (after breast cancer) in the western world. High metastatic relapse rates and severe side effects associated with the adjuvant treatment have urged oncologists and clinicians to find [...] Read more.
Colorectal cancer is the third most common cause of cancer-related deaths and the second most prevalent (after breast cancer) in the western world. High metastatic relapse rates and severe side effects associated with the adjuvant treatment have urged oncologists and clinicians to find a novel, less toxic therapeutic strategy. Considering the limited success of the past clinical trials involving peptide vaccine therapy to treat colorectal cancer, it is necessary to revise our knowledge of the immune system and its potential use in tackling cancer. This review presents the efforts of the scientific community in the development of peptide vaccine therapy for colorectal cancer. We review recent clinical trials and the strategies for immunologic monitoring of responses to peptide vaccine therapy. We also discuss the mechanisms underlying the therapy and potential molecular targets in colon cancer. Full article
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2 pages, 114 KB  
Editorial
Pathogens: A New Open Access Journal Serving All Those Interested in Infectious Disease
by Lawrence S. Young
Pathogens 2012, 1(1), 1-2; https://doi.org/10.3390/pathogens1010001 - 29 Sep 2011
Cited by 1 | Viewed by 5390
Abstract
Infection ranks alongside cardiovascular disease as the major cause of human death across the world. Word Health Organization data for 2002 shows that 26% of all deaths, almost 15 million in number, were due to infectious disease with HIV/AIDS, TB and malaria being [...] Read more.
Infection ranks alongside cardiovascular disease as the major cause of human death across the world. Word Health Organization data for 2002 shows that 26% of all deaths, almost 15 million in number, were due to infectious disease with HIV/AIDS, TB and malaria being the top three responsible infections. A significant proportion of these deaths were due to lower respiratory infections and diarrheal diseases in children. The worldwide morbidity associated with infectious disease is incalculable. When considered along with the consequences of infection in animals, it is hard to imagine any other disease that has such a significant impact on our lives―on health systems, on agriculture and on world economics. Our understanding of the agents responsible for infections―bacteria, fungi, parasites, prions and viruses―has an interesting history that heralds the great developments in modern biology and demonstrates how an understanding of disease pathogenesis can lead to successful prophylactic and therapeutic interventions. Van Leeuwenhoek’s first observation of bacteria under the light microscope, John Snow’s investigations tracing the source of a cholera epidemic in Victorian London’s Soho and Pasteur’s vaccines for rabies and anthrax contributed to an acceptance of the germ theory of disease and to the rational, scientific application of this knowledge to develop innovative disease control measures ranging from hygienic practices to antibiotics. [...] Full article
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