Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (1)

Search Parameters:
Keywords = medicinal ingredients
Page = 2

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
21 pages, 7259 KB  
Review
Recent Applications of Pd-Catalyzed Suzuki–Miyaura and Buchwald–Hartwig Couplings in Pharmaceutical Process Chemistry
by Balaram S. Takale, Fan-Yi Kong and Ruchita R. Thakore
Organics 2022, 3(1), 1-21; https://doi.org/10.3390/org3010001 - 18 Jan 2022
Cited by 42 | Viewed by 15929
Abstract
Cross-coupling reactions have changed the way complex molecules are synthesized. In particular, Suzuki–Miyaura and Buchwald–Hartwig amination reactions have given opportunities to elegantly make pharmaceutical ingredients. Indeed, these reactions are at the forefront of both the stages of drug development, medicinal chemistry, and process [...] Read more.
Cross-coupling reactions have changed the way complex molecules are synthesized. In particular, Suzuki–Miyaura and Buchwald–Hartwig amination reactions have given opportunities to elegantly make pharmaceutical ingredients. Indeed, these reactions are at the forefront of both the stages of drug development, medicinal chemistry, and process chemistry. On the one hand, these reactions have given medicinal chemists a resource to derivatize the core compound to arrive at scaffold rapidly. On the other hand, these cross couplings have offered the process chemists a smart tool to synthesize the development candidates safely, quickly, and efficiently. Generally, the application of cross-coupling reactions is broad. This review will specifically focus on their real (pharma) world applications in large-scale synthesis appearing in the last three years. Full article
(This article belongs to the Special Issue New Reactions and Strategies for Natural Product Synthesis)
Show Figures

Figure 1

Back to TopTop