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Keywords = BCL2 proteins
Page = 2

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16 pages, 494 KB  
Review
The Role of Apoptosis in the Pathology of Pancreatic Cancer
by Nicole Samm, Kristin Werner, Felix Rückert, Hans Detlev Saeger, Robert Grützmann and Christian Pilarsky
Cancers 2011, 3(1), 1-16; https://doi.org/10.3390/cancers3010001 - 23 Dec 2010
Cited by 22 | Viewed by 15063
Abstract
Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well [...] Read more.
Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway linked to the mitochondria. Defects in apoptotic pathways and the deregulation of apoptotic proteins, such as Survivin, Bcl-2, Bcl-xL and Mcl-1, play decisive roles in the development of pancreatic cancer. Investigation of the molecular mechanism allowing tumors to resist apoptotic cell death would lead to an improved understanding of the physiology and the development of new molecular strategies in pancreatic cancer. Full article
(This article belongs to the Special Issue Pancreatic Cancer)
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