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Authors = Wafa Safar

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49 pages, 11990 KiB  
Review
Conventional Raman, SERS and TERS Studies of DNA Compounds
by Wafa Safar, Aicha Azziz, Mathieu Edely and Marc Lamy de la Chapelle
Chemosensors 2023, 11(7), 399; https://doi.org/10.3390/chemosensors11070399 - 16 Jul 2023
Cited by 19 | Viewed by 4819
Abstract
DNA identification is possible by detecting its components through vibrational spectroscopy. Conventional Raman, Surface-enhanced Raman spectroscopy (SERS) and Tip-enhanced Raman spectroscopy (TERS) have shown a high capacity for the exploration of different molecules and materials (semi-conducting material, carbon nanotubes and biologicals molecules as [...] Read more.
DNA identification is possible by detecting its components through vibrational spectroscopy. Conventional Raman, Surface-enhanced Raman spectroscopy (SERS) and Tip-enhanced Raman spectroscopy (TERS) have shown a high capacity for the exploration of different molecules and materials (semi-conducting material, carbon nanotubes and biologicals molecules as DNA, proteins). Their applications extended to biological systems and brought significant information to this field. This review summarizes a high number of studies and research conducted with conventional Raman, SERS and TERS on every DNA component starting from the four different nucleic acids in their different forms (nucleosides, deoxyribonucleosides, deoxyribonucleotides) to their biological interaction to form one and double DNA strands. As SERS has an advantage on conventional Raman by exploiting the optical properties of metallic nanostructures to detect very small quantities of molecules, it also clarifies the DNA structure’s orientation in addition to its composition. It also clarifies the influence of different parameters, such as the presence of a spacer or a mutation in the strand on the hybridization process. TERS was shown as a relevant tool to scan DNA chemically and to provide information on its sequence. Full article
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12 pages, 2895 KiB  
Article
Gold Nanocylinders on Gold Film as a Multi-spectral SERS Substrate
by Wafa Safar, Médéric Lequeux, Jeanne Solard, Alexis P.A. Fischer, Nordin Felidj, Pietro Giuseppe Gucciardi, Mathieu Edely and Marc Lamy de la Chapelle
Nanomaterials 2020, 10(5), 927; https://doi.org/10.3390/nano10050927 - 11 May 2020
Cited by 15 | Viewed by 3842
Abstract
The surface enhanced Raman scattering (SERS) efficiency of gold nanocylinders deposited on gold thin film is studied. Exploiting the specific plasmonic properties of such substrates, we determine the influence of the nanocylinder diameter and the film thickness on the SERS signal at three [...] Read more.
The surface enhanced Raman scattering (SERS) efficiency of gold nanocylinders deposited on gold thin film is studied. Exploiting the specific plasmonic properties of such substrates, we determine the influence of the nanocylinder diameter and the film thickness on the SERS signal at three different excitation wavelengths (532, 638 and 785 nm). We demonstrate that the highest signal is reached for the highest diameter of 250 nm due to coupling between the nanocylinders and for the lowest thickness (20 nm) as the excited plasmon is created at the interface between the gold and glass substrate. Moreover, even if we show that the highest SERS efficiency is obtained for an excitation wavelength of 638 nm, a large SERS signal can be obtained at all excitation wavelengths and on a wide spectral range. We demonstrate that it can be related with the nature of the plasmon (propagative plasmon excited through the nanocylinder grating) and with its angular dependence (tuning of the plasmon position with the excitation angle). Such an effect allows the excitation of plasmon on nearly the whole visible range, and paves the way to multispectral SERS substrates. Full article
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