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Authors = Vito Di Gesu

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19 pages, 4543 KiB  
Article
Design and In Vitro Study of a Dual Drug-Loaded Delivery System Produced by Electrospinning for the Treatment of Acute Injuries of the Central Nervous System
by Luisa Stella Dolci, Rosaria Carmela Perone, Roberto Di Gesù, Mallesh Kurakula, Chiara Gualandi, Elisa Zironi, Teresa Gazzotti, Maria Teresa Tondo, Giampiero Pagliuca, Natalia Gostynska, Vito Antonio Baldassarro, Maura Cescatti, Luciana Giardino, Maria Letizia Focarete, Laura Calzà, Nadia Passerini and Maria Laura Bolognesi
Pharmaceutics 2021, 13(6), 848; https://doi.org/10.3390/pharmaceutics13060848 - 8 Jun 2021
Cited by 13 | Viewed by 4402
Abstract
Vascular and traumatic injuries of the central nervous system are recognized as global health priorities. A polypharmacology approach that is able to simultaneously target several injury factors by the combination of agents having synergistic effects appears to be promising. Herein, we designed a [...] Read more.
Vascular and traumatic injuries of the central nervous system are recognized as global health priorities. A polypharmacology approach that is able to simultaneously target several injury factors by the combination of agents having synergistic effects appears to be promising. Herein, we designed a polymeric delivery system loaded with two drugs, ibuprofen (Ibu) and thyroid hormone triiodothyronine (T3) to in vitro release the suitable amount of the anti-inflammation and the remyelination drug. As a production method, electrospinning technology was used. First, Ibu-loaded micro (diameter circa 0.95–1.20 µm) and nano (diameter circa 0.70 µm) fibers were produced using poly(l-lactide) PLLA and PLGA with different lactide/glycolide ratios (50:50, 75:25, and 85:15) to select the most suitable polymer and fiber diameter. Based on the in vitro release results and in-house knowledge, PLLA nanofibers (mean diameter = 580 ± 120 nm) loaded with both Ibu and T3 were then successfully produced by a co-axial electrospinning technique. The in vitro release studies demonstrated that the final Ibu/T3 PLLA system extended the release of both drugs for 14 days, providing the target sustained release. Finally, studies in cell cultures (RAW macrophages and neural stem cell-derived oligodendrocyte precursor cells—OPCs) demonstrated the anti-inflammatory and promyelinating efficacy of the dual drug-loaded delivery platform. Full article
(This article belongs to the Special Issue Multi-Target Drug Design for Complex Diseases)
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28 pages, 1977 KiB  
Article
Symmetry as an Intrinsically Dynamic Feature
by Vito Di Gesu, Marco E. Tabacchi and Bertrand Zavidovique
Symmetry 2010, 2(2), 554-581; https://doi.org/10.3390/sym2020554 - 1 Apr 2010
Cited by 7 | Viewed by 6539
Abstract
Symmetry is one of the most prominent spatial relations perceived by humans, and has a relevant role in attentive mechanisms regarding both visual and auditory systems. The aim of this paper is to establish symmetry, among the likes of motion, depth or range, [...] Read more.
Symmetry is one of the most prominent spatial relations perceived by humans, and has a relevant role in attentive mechanisms regarding both visual and auditory systems. The aim of this paper is to establish symmetry, among the likes of motion, depth or range, as a dynamic feature in artificial vision. This is achieved in the first instance by assessing symmetry estimation by means of algorithms, putting emphasis on erosion and multi-resolution approaches, and confronting two ensuing problems: the isolation of objects from the context, and the pertinence (or lack thereof) of some salient points, such as the centre of mass. Next a geometric model is illustrated and detailed, and the problem of measuring symmetry in a world where symmetry is not perfect nor the only attention trigger is tackled. Two algorithmic lines, based on the so-called symmetry kernel and its evolution with pattern warping, and by correlation of blocks with varying sizes and positions, are proposed and investigated. An extended illustration of the power of symmetry as a feature, based on face expression recognition, concludes the paper. Full article
(This article belongs to the Special Issue Feature Papers: Symmetry Concepts and Applications)
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