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Authors = Silvija Jakštienė

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6 pages, 497 KiB  
Article
Evaluation of pituitary imaging in patients with PROP-1 gene mutation
by Natalija Tkačenko, Danutė Lašienė, Silvija Jakštienė, Algidas Basevičius and Rasa Verkauskienė
Medicina 2009, 45(9), 693; https://doi.org/10.3390/medicina45090090 - 9 Sep 2009
Cited by 4 | Viewed by 1136
Abstract
The most common genetically determined cause of multiple pituitary hormone deficiency is PROP-1 gene mutation. PROP-1 is a transcription factor involved in the development of pituitary gland and affects hormonal synthesis of anterior pituitary.
The aim of our study
was to evaluate radiological [...] Read more.
The most common genetically determined cause of multiple pituitary hormone deficiency is PROP-1 gene mutation. PROP-1 is a transcription factor involved in the development of pituitary gland and affects hormonal synthesis of anterior pituitary.
The aim of our study
was to evaluate radiological aspects of the pituitary region in patients with PROP-1 gene mutation. Pituitary imaging studies were performed in 12 patients with a confirmed PROP-1 gene mutation. Pituitary hyperplasia was found in 5 (42%) and pituitary hypoplasia in 4 (33%) patients. Changes in pituitary size were not associated with the type of PROP-1 gene mutation. Full article
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