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Authors = Renáta Sklenářová ORCID = 0000-0001-7877-555X

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16 pages, 5139 KiB  
Article
3D-Printed Polycaprolactone Implants Modified with Bioglass and Zn-Doped Bioglass
by Izabella Rajzer, Anna Kurowska, Jana Frankova, Renáta Sklenářová, Anna Nikodem, Michał Dziadek, Adam Jabłoński, Jarosław Janusz, Piotr Szczygieł and Magdalena Ziąbka
Materials 2023, 16(3), 1061; https://doi.org/10.3390/ma16031061 - 25 Jan 2023
Cited by 17 | Viewed by 3243
Abstract
In this work, composite filaments in the form of sticks and 3D-printed scaffolds were investigated as a future component of an osteochondral implant. The first part of the work focused on the development of a filament modified with bioglass (BG) and Zn-doped BG [...] Read more.
In this work, composite filaments in the form of sticks and 3D-printed scaffolds were investigated as a future component of an osteochondral implant. The first part of the work focused on the development of a filament modified with bioglass (BG) and Zn-doped BG obtained by injection molding. The main outcome was the manufacture of bioactive, strong, and flexible filament sticks of the required length, diameter, and properties. Then, sticks were used for scaffold production. We investigated the effect of bioglass addition on the samples mechanical and biological properties. The samples were analyzed by scanning electron microscopy, optical microscopy, infrared spectroscopy, and microtomography. The effect of bioglass addition on changes in the SBF mineralization process and cell morphology was evaluated. The presence of a spatial microstructure within the scaffolds affects their mechanical properties by reducing them. The tensile strength of the scaffolds compared to filaments was lower by 58–61%. In vitro mineralization experiments showed that apatite formed on scaffolds modified with BG after 7 days of immersion in SBF. Scaffold with Zn-doped BG showed a retarded apatite formation. Innovative 3D-printing filaments containing bioglasses have been successfully applied to print bioactive scaffolds with the surface suitable for cell attachment and proliferation. Full article
(This article belongs to the Special Issue 3D Printing Functional Biomaterials)
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18 pages, 1291 KiB  
Review
Collagen as a Biomaterial for Skin and Corneal Wound Healing
by Renáta Sklenářová, Naoufal Akla, Meagan Jade Latorre, Jitka Ulrichová and Jana Franková
J. Funct. Biomater. 2022, 13(4), 249; https://doi.org/10.3390/jfb13040249 - 16 Nov 2022
Cited by 47 | Viewed by 9319
Abstract
The cornea and the skin are two organs that form the outer barrier of the human body. When either is injured (e.g., from surgery, physical trauma, or chemical burns), wound healing is initiated to restore integrity. Many cells are activated during wound healing. [...] Read more.
The cornea and the skin are two organs that form the outer barrier of the human body. When either is injured (e.g., from surgery, physical trauma, or chemical burns), wound healing is initiated to restore integrity. Many cells are activated during wound healing. In particular, fibroblasts that are stimulated often transition into repair fibroblasts or myofibroblasts that synthesize extracellular matrix (ECM) components into the wound area. Control of wound ECM deposition is critical, as a disorganized ECM can block restoration of function. One of the most abundant structural proteins in the mammalian ECM is collagen. Collagen type I is the main component in connective tissues. It can be readily obtained and purified, and short analogs have also been developed for tissue engineering applications, including modulating the wound healing response. This review discusses the effect of several current collagen implants on the stimulation of corneal and skin wound healing. These range from collagen sponges and hydrogels to films and membranes. Full article
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