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Authors = Ramatullah Qurishi

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12 pages, 103 KiB  
Article
Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A2A Receptor Antagonist MSX-2
by Karl Vollmann, Ramatullah Qurishi, Jörg Hockemeyer and Christa E. Müller
Molecules 2008, 13(2), 348-359; https://doi.org/10.3390/molecules13020348 - 12 Feb 2008
Cited by 42 | Viewed by 12465
Abstract
The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargylxanthine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an aminoacid ester prodrug of the adenosine A2A receptor antagonist MSX-2. It was found to bestable in artificial gastric acid, but readily cleaved by pig liver esterase. Full article
(This article belongs to the Special Issue Prodrugs)
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