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Authors = Ozlem Ipek Kalaoglu-Altan

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17 pages, 5312 KiB  
Article
Silver Nanoparticle-Coated Polyhydroxyalkanoate Based Electrospun Fibers for Wound Dressing Applications
by Ozlem Ipek Kalaoglu-Altan, Havva Baskan, Timo Meireman, Pooja Basnett, Bahareh Azimi, Alessandra Fusco, Niccola Funel, Giovanna Donnarumma, Andrea Lazzeri, Ipsita Roy, Serena Danti and Karen De Clerck
Materials 2021, 14(17), 4907; https://doi.org/10.3390/ma14174907 - 28 Aug 2021
Cited by 19 | Viewed by 4108
Abstract
Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nanofabrication and antimicrobial [...] Read more.
Wound dressings are high performance and high value products which can improve the regeneration of damaged skin. In these products, bioresorption and biocompatibility play a key role. The aim of this study is to provide progress in this area via nanofabrication and antimicrobial natural materials. Polyhydroxyalkanoates (PHAs) are a bio-based family of polymers that possess high biocompatibility and skin regenerative properties. In this study, a blend of poly(3-hydroxybutyrate) (P(3HB)) and poly(3-hydroxyoctanoate-co-3-hydroxy decanoate) (P(3HO-co-3HD)) was electrospun into P(3HB))/P(3HO-co-3HD) nanofibers to obtain materials with a high surface area and good handling performance. The nanofibers were then modified with silver nanoparticles (AgNPs) via the dip-coating method. The silver-containing nanofiber meshes showed good cytocompatibility and interesting immunomodulatory properties in vitro, together with the capability of stimulating the human beta defensin 2 and cytokeratin expression in human keratinocytes (HaCaT cells), which makes them promising materials for wound dressing applications. Full article
(This article belongs to the Special Issue Low-Impact Polymer Nanofibers and Applications)
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12 pages, 14759 KiB  
Article
Development of Bionanocomposites Based on Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate)/PolylActide Blends Reinforced with Cloisite 30B
by Clément Lacoste, Benjamin Gallard, José-Marie Lopez-Cuesta, Ozlem Ipek Kalaoglu-Altan and Karen De Clerck
J. Funct. Biomater. 2020, 11(3), 64; https://doi.org/10.3390/jfb11030064 - 16 Sep 2020
Cited by 11 | Viewed by 2930
Abstract
In the present study, poly(3-hydroxybuturate-co-3-hydroxyvalerate) (PHBV) and plasticized polylactide acid (PLA) blends were processed by melt extrusion with different weight ratio (up to 20 wt.% of PHBV). Bionanocomposites were obtained through the incorporation of an organomodified montmorillonite (C30B) at 3 wt.%. The main [...] Read more.
In the present study, poly(3-hydroxybuturate-co-3-hydroxyvalerate) (PHBV) and plasticized polylactide acid (PLA) blends were processed by melt extrusion with different weight ratio (up to 20 wt.% of PHBV). Bionanocomposites were obtained through the incorporation of an organomodified montmorillonite (C30B) at 3 wt.%. The main features of the processing and physico-chemical characterization of films and injected samples were assessed and the influence of the components on the chemical, thermal and mechanical properties of the bionanocomposites was investigated. The results indicated that plasticized PLA/PHBV/C30B bionanocomposites present optimal mechanical properties for sanitary applications. Moreover, plasticized PLA/PHBV could lead to finely tuned biomaterials able to form electrospun nanofibers. Full article
(This article belongs to the Special Issue High Performance Functional Bio-based Polymers for Skin-contact Products)
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17 pages, 11862 KiB  
Article
Electrosprayed Chitin Nanofibril/Electrospun Polyhydroxyalkanoate Fiber Mesh as Functional Nonwoven for Skin Application
by Bahareh Azimi, Lily Thomas, Alessandra Fusco, Ozlem Ipek Kalaoglu-Altan, Pooja Basnett, Patrizia Cinelli, Karen De Clerck, Ipsita Roy, Giovanna Donnarumma, Maria-Beatrice Coltelli, Serena Danti and Andrea Lazzeri
J. Funct. Biomater. 2020, 11(3), 62; https://doi.org/10.3390/jfb11030062 - 3 Sep 2020
Cited by 53 | Viewed by 6686
Abstract
Polyhydroxyalkanoates (PHAs) are a family of bio-based polyesters that have found different biomedical applications. Chitin and lignin, byproducts of fishery and plant biomass, show antimicrobial and anti-inflammatory activity on the nanoscale. Due to their polarities, chitin nanofibril (CN) and nanolignin (NL) can be [...] Read more.
Polyhydroxyalkanoates (PHAs) are a family of bio-based polyesters that have found different biomedical applications. Chitin and lignin, byproducts of fishery and plant biomass, show antimicrobial and anti-inflammatory activity on the nanoscale. Due to their polarities, chitin nanofibril (CN) and nanolignin (NL) can be assembled into micro-complexes, which can be loaded with bioactive factors, such as the glycyrrhetinic acid (GA) and CN-NL/GA (CLA) complexes, and can be used to decorate polymer surfaces. This study aims to develop completely bio-based and bioactive meshes intended for wound healing. Poly(3-hydroxybutyrate)/Poly(3-hydroxyoctanoate-co-3-hydroxydecanoate), P(3HB)/P(3HO-co-3HD) was used to produce films and fiber meshes, to be surface-modified via electrospraying of CN or CLA to reach a uniform distribution. P(3HB)/P(3HO-co-3HD) fibers with desirable size and morphology were successfully prepared and functionalized with CN and CLA using electrospinning and tested in vitro with human keratinocytes. The presence of CN and CLA improved the indirect antimicrobial and anti-inflammatory activity of the electrospun fiber meshes by downregulating the expression of the most important pro-inflammatory cytokines and upregulating human defensin 2 expression. This natural and eco-sustainable mesh is promising in wound healing applications. Full article
(This article belongs to the Special Issue High Performance Functional Bio-based Polymers for Skin-contact Products)
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