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Authors = Nadia Z. Masri

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18 pages, 1621 KiB  
Review
Smart Bioinks for the Printing of Human Tissue Models
by Zeina Maan, Nadia Z. Masri and Stephanie M. Willerth
Biomolecules 2022, 12(1), 141; https://doi.org/10.3390/biom12010141 - 15 Jan 2022
Cited by 31 | Viewed by 6539
Abstract
3D bioprinting has tremendous potential to revolutionize the field of regenerative medicine by automating the process of tissue engineering. A significant number of new and advanced bioprinting technologies have been developed in recent years, enabling the generation of increasingly accurate models of human [...] Read more.
3D bioprinting has tremendous potential to revolutionize the field of regenerative medicine by automating the process of tissue engineering. A significant number of new and advanced bioprinting technologies have been developed in recent years, enabling the generation of increasingly accurate models of human tissues both in the healthy and diseased state. Accordingly, this technology has generated a demand for smart bioinks that can enable the rapid and efficient generation of human bioprinted tissues that accurately recapitulate the properties of the same tissue found in vivo. Here, we define smart bioinks as those that provide controlled release of factors in response to stimuli or combine multiple materials to yield novel properties for the bioprinting of human tissues. This perspective piece reviews the existing literature and examines the potential for the incorporation of micro and nanotechnologies into bioinks to enhance their properties. It also discusses avenues for future work in this cutting-edge field. Full article
(This article belongs to the Special Issue State-of-the-Art Biochemistry and Molecular Biology in USA 2021-2022)
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19 pages, 938 KiB  
Review
Natural Biomaterials and Their Use as Bioinks for Printing Tissues
by Claire Benwood, Josie Chrenek, Rebecca L. Kirsch, Nadia Z. Masri, Hannah Richards, Kyra Teetzen and Stephanie M. Willerth
Bioengineering 2021, 8(2), 27; https://doi.org/10.3390/bioengineering8020027 - 20 Feb 2021
Cited by 173 | Viewed by 15077
Abstract
The most prevalent form of bioprinting—extrusion bioprinting—can generate structures from a diverse range of materials and viscosities. It can create personalized tissues that aid in drug testing and cancer research when used in combination with natural bioinks. This paper reviews natural bioinks and [...] Read more.
The most prevalent form of bioprinting—extrusion bioprinting—can generate structures from a diverse range of materials and viscosities. It can create personalized tissues that aid in drug testing and cancer research when used in combination with natural bioinks. This paper reviews natural bioinks and their properties and functions in hard and soft tissue engineering applications. It discusses agarose, alginate, cellulose, chitosan, collagen, decellularized extracellular matrix, dextran, fibrin, gelatin, gellan gum, hyaluronic acid, Matrigel, and silk. Multi-component bioinks are considered as a way to address the shortfalls of individual biomaterials. The mechanical, rheological, and cross-linking properties along with the cytocompatibility, cell viability, and printability of the bioinks are detailed as well. Future avenues for research into natural bioinks are then presented. Full article
(This article belongs to the Special Issue 3D Bioprinting for Tissue Engineering and Regenerative Medicine)
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