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Authors = Min-Rui Tai

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16 pages, 3022 KiB  
Article
Insights into the Mechanism Underpinning Composite Molecular Docking During the Self-Assembly of Fucoidan Biopolymers with Peptide Nanofibrils
by Rui Li, Min-Rui Tai, Xian-Ni Su, Hong-Wu Ji, Jian-Ping Chen, Xiao-Fei Liu, Bing-Bing Song, Sai-Yi Zhong, David. R. Nisbet, Colin J. Barrow and Richard J. Williams
Mar. Drugs 2025, 23(4), 169; https://doi.org/10.3390/md23040169 - 15 Apr 2025
Cited by 1 | Viewed by 643
Abstract
Composite hydrogels with improved mechanical and chemical properties can be formed by non-covalently decorating the nanofibrillar structures formed by the self-assembly of peptides with fucoidan. Nevertheless, the precise interactions, and the electrochemical and thermodynamic stability of these composite materials have not been determined. [...] Read more.
Composite hydrogels with improved mechanical and chemical properties can be formed by non-covalently decorating the nanofibrillar structures formed by the self-assembly of peptides with fucoidan. Nevertheless, the precise interactions, and the electrochemical and thermodynamic stability of these composite materials have not been determined. Here, we present a thermodynamic analysis of the interacting forces that drive the formation of a composite fucoidan/9-fluorenylmethoxycarbonyl-phenylalanine-arginine-glycine-aspartic acid-phenylalanine (Fmoc-FRGDF) hydrogel. The results showed that the co-assembly of fucoidan and Fmoc-FRGDF was spontaneous and exothermic. The melting point increased from 87.0 °C to 107.7 °C for Fmoc-FRGDF with 8 mg/mL of added fucoidan. A complex network of hydrogen bonds formed between the molecules of Fmoc-FRGDF, and electrostatic, hydrogen bond, and van der Waals interactions were the main interactions driving the co-assembly of fucoidan and Fmoc-FRGDF. Furthermore, the sulfate group of fucoidan formed a strong salt bridge with the arginine of Fmoc-FRGDF. This study provides useful biomedical engineering design parameters for the inclusion of other highly soluble biopolymers into these types of hydrogel vectors. Full article
(This article belongs to the Special Issue Marine Polysaccharides-Based Biomaterials)
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23 pages, 985 KiB  
Review
Simple Complexity: Incorporating Bioinspired Delivery Machinery within Self-Assembled Peptide Biogels
by Rui Li, Qing-Ling Zhou, Min-Rui Tai, Kathryn Ashton-Mourney, Mathew I. Harty, Aaqil Rifai, Clare L. Parish, David R. Nisbet, Sai-Yi Zhong and Richard J. Williams
Gels 2023, 9(3), 199; https://doi.org/10.3390/gels9030199 - 6 Mar 2023
Cited by 15 | Viewed by 3410
Abstract
Bioinspired self-assembly is a bottom-up strategy enabling biologically sophisticated nanostructured biogels that can mimic natural tissue. Self-assembling peptides (SAPs), carefully designed, form signal-rich supramolecular nanostructures that intertwine to form a hydrogel material that can be used for a range of cell and tissue [...] Read more.
Bioinspired self-assembly is a bottom-up strategy enabling biologically sophisticated nanostructured biogels that can mimic natural tissue. Self-assembling peptides (SAPs), carefully designed, form signal-rich supramolecular nanostructures that intertwine to form a hydrogel material that can be used for a range of cell and tissue engineering scaffolds. Using the tools of nature, they are a versatile framework for the supply and presentation of important biological factors. Recent developments have shown promise for many applications such as therapeutic gene, drug and cell delivery and yet are stable enough for large-scale tissue engineering. This is due to their excellent programmability—features can be incorporated for innate biocompatibility, biodegradability, synthetic feasibility, biological functionality and responsiveness to external stimuli. SAPs can be used independently or combined with other (macro)molecules to recapitulate surprisingly complex biological functions in a simple framework. It is easy to accomplish localized delivery, since they can be injected and can deliver targeted and sustained effects. In this review, we discuss the categories of SAPs, applications for gene and drug delivery, and their inherent design challenges. We highlight selected applications from the literature and make suggestions to advance the field with SAPs as a simple, yet smart delivery platform for emerging BioMedTech applications. Full article
(This article belongs to the Special Issue Gels in Medicine and Pharmacological Therapies)
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15 pages, 1602 KiB  
Article
Chemical Characterization and Immunomodulatory Activity of Fucoidan from Sargassum hemiphyllum
by Rui Li, Qing-Ling Zhou, Shu-Tong Chen, Min-Rui Tai, Hong-Ying Cai, Rui Ding, Xiao-Fei Liu, Jian-Ping Chen, Lian-Xiang Luo and Sai-Yi Zhong
Mar. Drugs 2023, 21(1), 18; https://doi.org/10.3390/md21010018 - 26 Dec 2022
Cited by 22 | Viewed by 4423
Abstract
Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w [...] Read more.
Fucoidan is a sulfated algal polyanionic polysaccharide that possesses many biological activities. In this paper, a fucoidan (SHF) polysaccharide was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa (44.06%, w/w), consisted of glucose (32.68%, w/w), galactose (24.81%, w/w), fucose (20.75%, w/w), xylose (6.98%, w/w), mannose (2.76%, w/w), other neutral monosaccharides, and three uronic acids, including glucuronic acid (5.39%, w/w), mannuronic acid (1.76%, w/w), and guronuronic acid (1.76%, w/w). The SHF exhibited excellent immunostimulatory activity. An immunostimulating assay showed that SHF could significantly increase NO secretion in macrophage RAW 264.7 cells via upregulation of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) levels based on both gene expression and protein abundance. These results suggest that SHF isolated from Sargassum hemiphyllum has great potential to act as a health-boosting ingredient in the pharmaceutical and functional-food fields. Full article
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