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Authors = Melanie KROJER

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10 pages, 138 KiB  
Article
7-Aza-des-A-steroids with Antimicrobial and Cytotoxic Activity
by Melanie KROJER, Marco KELLER and Franz BRACHER
Sci. Pharm. 2013, 81(2), 329-338; https://doi.org/10.3797/scipharm.1303-03 - 14 Apr 2013
Cited by 10 | Viewed by 1480
Abstract
This paper describes a convenient approach to the 7-aza-des-A-steroid (6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[h]quinoline) scaffold starting from Grundmann's ketone using two different pyridine annulation protocols. The biological evaluation of the pyridine and pyridinium products revealed that these compounds unexpectedly do not [...] Read more.
This paper describes a convenient approach to the 7-aza-des-A-steroid (6,6a,7,8,9,9a-hexahydro-5H-cyclopenta[h]quinoline) scaffold starting from Grundmann's ketone using two different pyridine annulation protocols. The biological evaluation of the pyridine and pyridinium products revealed that these compounds unexpectedly do not interfere with ergosterol and cholesterol biosynthesis. The pyridinium compound 6 showed significant antimicrobial and cytotoxic activities which are most likely due to its detergent-like structure. Full article
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