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Authors = Marcello Vannucci Tedardi

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22 pages, 3457 KiB  
Review
Comparative Aspects of Canine Melanoma
by Adriana Tomoko Nishiya, Cristina Oliveira Massoco, Claudia Ronca Felizzola, Eduardo Perlmann, Karen Batschinski, Marcello Vannucci Tedardi, Jéssica Soares Garcia, Priscila Pedra Mendonça, Tarso Felipe Teixeira and Maria Lucia Zaidan Dagli
Vet. Sci. 2016, 3(1), 7; https://doi.org/10.3390/vetsci3010007 - 19 Feb 2016
Cited by 107 | Viewed by 25204
Abstract
Melanomas are malignant neoplasms originating from melanocytes. They occur in most animal species, but the dog is considered the best animal model for the disease. Melanomas in dogs are most frequently found in the buccal cavity, but the skin, eyes, and digits are [...] Read more.
Melanomas are malignant neoplasms originating from melanocytes. They occur in most animal species, but the dog is considered the best animal model for the disease. Melanomas in dogs are most frequently found in the buccal cavity, but the skin, eyes, and digits are other common locations for these neoplasms. The aim of this review is to report etiological, epidemiological, pathological, and molecular aspects of melanomas in dogs. Furthermore, the particular biological behaviors of these tumors in the different body locations are shown. Insights into the therapeutic approaches are described. Surgery, chemotherapy, radiotherapy, immunotherapy, and the outcomes after these treatments are presented. New therapeutic perspectives are also depicted. All efforts are geared toward better characterization and control of malignant melanomas in dogs, for the benefit of these companion animals, and also in an attempt to benefit the treatment of human melanomas. Full article
(This article belongs to the Special Issue Comparative Pathogenesis of Cancers in Animals and Humans)
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