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Authors = Leônidas Das Graças Mendes Junior

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9 pages, 1038 KiB  
Article
Alkaloids and Phenolic Compounds from Sida rhombifolia L. (Malvaceae) and Vasorelaxant Activity of Two Indoquinoline Alkaloids
by Otemberg Souza Chaves, Yanna Carolina Ferreira Teles, Matheus Morais de Oliveira Monteiro, Leônidas Das Graças Mendes Junior, Maria De Fátima Agra, Valdir De Andrade Braga, Tânia Maria Sarmento Silva and Maria De Fátima Vanderlei de Souza
Molecules 2017, 22(1), 94; https://doi.org/10.3390/molecules22010094 - 6 Jan 2017
Cited by 48 | Viewed by 9069
Abstract
The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial [...] Read more.
The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods. The study led to the isolation of scopoletin (1), scoporone (2), ethoxy-ferulate (3), kaempferol (4), kaempferol-3-O-β-d-glycosyl-6′′-α-d-rhamnose (5), quindolinone (6), 11-methoxy-quindoline (7), quindoline (8), and the cryptolepine salt (9). The alkaloids quindolinone (6) and cryptolepine salt (9) showed vasorelaxant activity in rodent isolated mesenteric arteries. Full article
(This article belongs to the Section Natural Products Chemistry)
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9 pages, 302 KiB  
Article
Secondary Metabolites from Sida rhombifolia L. (Malvaceae) and the Vasorelaxant Activity of Cryptolepinone
by Otemberg Souza Chaves, Roosevelt Albuquerque Gomes, Anna Cláudia de Andrade Tomaz, Marianne Guedes Fernandes, Leônidas Das Graças Mendes Junior, Maria De Fátima Agra, Valdir Andrade Braga and Maria De Fátima Vanderlei de Souza
Molecules 2013, 18(3), 2769-2777; https://doi.org/10.3390/molecules18032769 - 1 Mar 2013
Cited by 43 | Viewed by 9632
Abstract
The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-b-D-glucopyranoside (2a) and stigmasterol-3-O-b-D-glucopyranoside (2b), phaeophytin A [...] Read more.
The phytochemical study of Sida rhombifolia L. (Malvaceae) led to the isolation through chromatographic techniques of eleven secondary metabolites: sitosterol (1a) and stigmasterol (1b), sitosterol-3-O-b-D-glucopyranoside (2a) and stigmasterol-3-O-b-D-glucopyranoside (2b), phaeophytin A (3), 173-ethoxypheophorbide A (4), 132-hydroxy phaeophytin B (5), 173-ethoxypheophorbide B (6), 5,7-dihydroxy-4'-methoxyflavone (7), cryptolepinone (8) and a salt of cryptolepine (9). Their structures were identified by 1H- and 13C-NMR using one- and two-dimensional techniques. In addition, the vasorelaxant activity of cryptolepinone in rat mesenteric artery rings is reported herein for the first time. Full article
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