Search Results (4)

Tyrimo tikslas. Ištirti p53 baltymo ir HER2 (c-erbB-2) receptorių padidėjusios raiškos įtaką II stadijos krūties vėžiu sirgusių jaunų moterų penkerių metų išgyvenamumui, atsižvelgiant į hormonų receptorių bei gydymo savitumų reikšmę. Tyrimo medžiaga ir metodai. Retrospektyviai analizuojama 34 Kauno apskrities moterų, gydytų 2001–2003 m. Kauno onkologijos ligoninėje, medicininė dokumentacija ir archyvinė histologinė medžiaga. Tiriamųjų kontingentas – jaunos, iki 50 metų moterys, kurioms diagnozuotas ir morfologiškai patvirtintas II stadijos krūties vėžys. 22 moterys išgyveno penkerius metus, 12 mirė penkerių metų laikotarpiu. Panaudojant archyvinę histologinę medžiagą de novo, tuometinėje KMUK Patologinės anatomijos klinikoje buvo atliktas p53 baltymo ir HER2 receptorių raiškos tyrimas imunohistocheminiu metodu. Panaudojant medicininę dokumentaciją, analizuota pacientėms skirta adjuvantinė chemoterapija, antraciklinų suminė dozė ir hormoninis gydymas.
Rezultatai. Tarp visų 34 tiriamųjų 20,6 proc. atvejų rasta padidėjusi p53 baltymo raiška, 26,4 proc. atvejų – HER2 baltymo raiška. Analizuojant išgyvenamumą Kaplan-Meier metodu, nustatyta, kad mirties tikimybė penkerių metų laikotarpiu didesnė, kai naviko histologinėje medžiagoje rastas padidėjęs p53 baltymo kaupimasis, neigiami estrogenų receptoriai ir kai pacientės gydytos nepakankama antraciklino doze (log rank p=0,013, log rank p=0,02, log rank p=0,027, atitinkamai). Nerasta sąsajų tarp padidėjusios HER2 baltymo raiškos ir pacienčių penkerių metų išgyvenimo (log rank p=0,51). Daugiamatės analizės metodu nustatyta, kad vienintelis nepriklausomas veiksnys yra nepakankama antraciklinų dozė (p=0,028).
Išvada. Jaunų moterų, susirgusių II stadijos krūties vėžiu, trumpesnei gyvenimo trukmei įtakos turi padidėjusi p53 baltymo raiška, sumažinta antraciklinų dozė ir neigiami estrogenų receptoriai, o HER2 baltymo padidėjusios raiškos įtakos penkerių metų gyvenimo trukmei nepavyko įrodyti. Nepriklausomas prognozinis veiksnys yra nepakankamas adjuvantinis gydymas antraciklinais. Full article

The aim of the study was to compare the quality of life between stroke survivors and controls with respect to their health, daily activities, and emotional status.
Contingent and methods of the study. The studied group consisted of 508 25–84-year-old inhabitants of Kaunas city who have survived first-onset stroke. The control group consisted of 508 age- and sex-matched randomly selected inhabitants of Kaunas city who had not experienced stroke. The SF-12 Quality of Life Questionnaire was used for the study. Logistic regression was used to compare quality of life with respect to health, daily activities, and emotional status.
Results. Only 1.0% of stroke survivors evaluated their health as excellent or very good, compared to 24.4% of the controls (P=0.0005); the respective percentages of those who evaluated their health as poor or fair were 78.9% and 26.4% (P=0.0005). Health significantly limited moderate activities in 35.2% of stroke survivors and 3.5% of controls (P=0.0005). During the last 4 weeks, health status or emotional problems most of the time or a little of the time impeded social activities in 19.3% of stroke survivors and 1.6% of controls (P<0.05). When comparing with respect to age, sex, and diseases (arterial hypertension, myocardial infarction, atrial fibrillation, diabetes mellitus, transient ischemic attack), stroke had the greatest negative effect on social activities (odds ratio, 36.7), caused sadness (odds ratio, 16.0), and significantly limited home activities (odds ratio, 15.5).
Conclusions. Less that one-third (28.2%) of stroke survivors evaluated their health as poor, and 50.7% as fair as compared to 1.8% and 24.6% of controls, respectively. Stroke significantly impaired the subjects’ emotional status and limited their daily activities. Full article

The aim of the study was to compare the quality of life among stroke survivors and healthy controls and to evaluate the influence of age, sex, and social and demographic factors on the quality of life.
Contingent and methods. The case group consisted of 508 inhabitants of Kaunas city who were 25–84 years of age and had experienced their first stroke. The control group consisted of age- and sex-stratified randomly selected 508 stroke-free inhabitants of Kaunas city. The quality of life was evaluated using the SF- 12 questionnaire. The study compared the quality of life between stroke survivors and controls in eight domains of quality of life and compared the evaluation of quality of life considering social and demographic features.
Results. In the domain of physical and mental health, stroke survivors presented poorer evaluation of their quality of life compared to controls except for the evaluations of mental health in the age groups of 25–34 and 35–44 years. As compared to healthy controls, stroke survivors presented poorer evaluation of their quality of life in all domains except for pain. Only in the control group, females presented poorer evaluation of physical health, whereas no differences in the evaluation of mental health between sexes were found. The evaluation of physical health in both groups worsened with age. Both stroke survivors and controls presented better evaluation of their physical health if they were living not alone, were better educated, and were employed compared to those who were living alone, had poorer education level, and were unemployed. In addition, controls who were currently or previously engaged in mental work evaluated their physical health better.
Conclusions. Stroke survivors presented poorer evaluations of their quality of life in both physical and mental health domains compared to controls. Only in the control group, females evaluated their physical health worse than males did. In both groups studied, poorer evaluation of physical health was associated with older age and lower social and demographic status. Relationship between mental health and subjects’ social and demographic status was not statistically significant in either of the studied groups. Full article

The aim of the study was to evaluate the suitability of the SF-12 questionnaire for the evaluation of the quality of life in 25–84-year-old inhabitants of Kaunas city and to compare quality of life between men and women as well as between socially and demographically different groups.
Material and methods. The study sample consisted of randomly selected inhabitants of Kaunas city, stratified by age and sex. The suitability of the questionnaire for the evaluation of the quality of life in the selected contingent was verified using Cronbach’s alpha coefficient. The convergent validity of the questionnaire was assessed by the strength of the linear relationship between the domains of the questionnaire, calculating Pearson’s correlation coefficients. We calculated mean ranges of the values of the questionnaire and compared the distribution of values.
Results. Cronbach’s alpha values indicated a very strong internal consistency of the mental and physical domains of the SF-12 questionnaire (0.87 and 0.88, respectively). Women reported lower quality of life in the domains of mental health and physical health-pain as compared to men. People who were not living alone, with higher level of education, and employed reported better physical and mental health than those living alone, with lower level of education, or unemployed. In addition to that, people who were engaged in mental work during the study or had worked such work before reported better physical and mental health.
Conclusions. The questionnaire SF-12 is suitable for the evaluation of the quality of life in the population of Kaunas city. Women reported lower quality of life in mental health domain than men did. The evaluations of the quality of life worsened with increasing age and lower social and demographic status. Full article