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Authors = Kazutoshi Hasegawa

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10 pages, 1861 KiB  
Article
A Phase Ib Study of Durvalumab (MEDI4736) in Combination with Carbon-Ion Radiotherapy and Weekly Cisplatin for Patients with Locally Advanced Cervical Cancer (DECISION Study): The Early Safety and Efficacy Results
by Noriyuki Okonogi, Kazutoshi Murata, Shigeru Yamada, Yuji Habu, Makoto Hori, Tomoya Kurokawa, Yosuke Inaba, Tadami Fujiwara, Yasuhisa Fujii, Michiko Hanawa, Yohei Kawasaki, Yoko Hattori, Kazuko Suzuki, Kyoko Tsuyuki, Masaru Wakatsuki, Masashi Koto, Sumitaka Hasegawa, Hitoshi Ishikawa, Hideki Hanaoka, Makio Shozu, Hiroshi Tsuji and Hirokazu Usuiadd Show full author list remove Hide full author list
Int. J. Mol. Sci. 2023, 24(13), 10565; https://doi.org/10.3390/ijms241310565 - 23 Jun 2023
Cited by 4 | Viewed by 2660
Abstract
We conducted a phase Ib study to examine the safety of a combination of carbon-ion RT (CIRT) with durvalumab (MEDI4736; AstraZeneca) in patients with locally advanced cervical cancer. This was an open-label, single-arm study with a modified 3 + 3 design. Patients with [...] Read more.
We conducted a phase Ib study to examine the safety of a combination of carbon-ion RT (CIRT) with durvalumab (MEDI4736; AstraZeneca) in patients with locally advanced cervical cancer. This was an open-label, single-arm study with a modified 3 + 3 design. Patients with newly diagnosed histologically proven locally advanced cervical cancer were enrolled. All patients received 74.4 Gy of CIRT in 20 fractions and concurrent weekly cisplatin (chemo-CIRT) at a dose of 40 mg/m2. Durvalumab was administered (1500 mg/body) at weeks two and six. The primary endpoint was the incidence of adverse events (AEs) and serious AEs (SAEs), including dose-limiting toxicity (DLT). All three enrolled patients completed the treatment without interruption. One patient developed hypothyroidism after treatment and was determined to be an SAE. No other SAEs were observed. The patient recovered after levothyroxine sodium hydrate treatment. None of the AEs, including hypothyroidism, were associated with DLT in the present study. All three patients achieved complete responses within the CIRT region concerning treatment efficacy. This phase 1b trial demonstrates the safety of combining chemo-CIRT and durvalumab for locally advanced cervical cancer in the early phase. Further research is required as only three patients were included in this study. Full article
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11 pages, 1274 KiB  
Article
Removal of Pb (II) from Aqueous Solution by a Pectin-Producing Alga, Penium margaritaceum, Immobilized on Filter Paper
by Tsogjargal Byamba, Kazutoshi Hasegawa and Isamu Maeda
Microbiol. Res. 2022, 13(4), 1007-1017; https://doi.org/10.3390/microbiolres13040073 - 10 Dec 2022
Cited by 3 | Viewed by 3279
Abstract
Lead (Pb) pollution from local mines and industrial use increases risks for human, animal, and plant health. Pectin is an effective chelator of Pb, and it has been shown that a unicellular green alga, Penium margaritaceum, synthesizes pectin in the cell wall. [...] Read more.
Lead (Pb) pollution from local mines and industrial use increases risks for human, animal, and plant health. Pectin is an effective chelator of Pb, and it has been shown that a unicellular green alga, Penium margaritaceum, synthesizes pectin in the cell wall. In this study, the ability of P. margaritaceum to remove Pb from an aqueous solution was investigated. Energy dispersive X-ray spectroscopy revealed that two strains of P. margaritaceum accumulated Pb on the cell surface. Hence, P. margaritaceum cells were immobilized on cellulose filter paper. The immobilized algal cells were soaked in 1.0 mg/L Pb solution with gentle shaking for 8 h, and Pb in the solution and on the filter paper was measured by flame atomic absorption spectrometry. The immobilized algal cells continuously decreased the Pb concentration to less than 0.5 mg/L and recovered 31.8–32.7% of added Pb. The specific decrease in Pb and increase in Ca were observed in the presence of 1.0 mg/L each of Ca, Mg, Na, and K. Fourier transform infrared spectra suggested that the carboxylic acid group would be responsible for the adsorption of Pb. This study is the first to demonstrate the effectiveness of the immobilized P. margaritaceum cell in removing Pb from aqueous solutions with simple solid–liquid separation. Full article
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