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Authors = Guido Torelli

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12 pages, 1807 KiB  
Article
ZnO Thin Films Growth Optimization for Piezoelectric Application
by Vincent Polewczyk, Riccardo Magrin Maffei, Giovanni Vinai, Matteo Lo Cicero, Stefano Prato, Pietro Capaldo, Simone Dal Zilio, Alessandro di Bona, Guido Paolicelli, Andrea Mescola, Sergio D’Addato, Piero Torelli and Stefania Benedetti
Sensors 2021, 21(18), 6114; https://doi.org/10.3390/s21186114 - 12 Sep 2021
Cited by 15 | Viewed by 4900
Abstract
The piezoelectric response of ZnO thin films in heterostructure-based devices is strictly related to their structure and morphology. We optimize the fabrication of piezoelectric ZnO to reduce its surface roughness, improving the crystalline quality, taking into consideration the role of the metal electrode [...] Read more.
The piezoelectric response of ZnO thin films in heterostructure-based devices is strictly related to their structure and morphology. We optimize the fabrication of piezoelectric ZnO to reduce its surface roughness, improving the crystalline quality, taking into consideration the role of the metal electrode underneath. The role of thermal treatments, as well as sputtering gas composition, is investigated by means of atomic force microscopy and x-ray diffraction. The results show an optimal reduction in surface roughness and at the same time a good crystalline quality when 75% O2 is introduced in the sputtering gas and deposition is performed between room temperature and 573 K. Subsequent annealing at 773 K further improves the film quality. The introduction of Ti or Pt as bottom electrode maintains a good surface and crystalline quality. By means of piezoelectric force microscope, we prove a piezoelectric response of the film in accordance with the literature, in spite of the low ZnO thickness and the reduced grain size, with a unipolar orientation and homogenous displacement when deposited on Ti electrode. Full article
(This article belongs to the Special Issue Piezoelectric Nano Structures for Sensor and Applications)
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20 pages, 1868 KiB  
Article
A Phase 1 Randomized Placebo-Controlled Study to Assess the Safety, Immunogenicity and Genetic Stability of a New Potential Pandemic H7N9 Live Attenuated Influenza Vaccine in Healthy Adults
by Irina Kiseleva, Irina Isakova-Sivak, Marina Stukova, Marianna Erofeeva, Svetlana Donina, Natalie Larionova, Elena Krutikova, Ekaterina Bazhenova, Ekaterina Stepanova, Kirill Vasilyev, Victoria Matyushenko, Marina Krylova, Julia Galatonova, Aleksey Ershov, Dmitry Lioznov, Erin Grace Sparrow, Guido Torelli and Larisa Rudenko
Vaccines 2020, 8(2), 296; https://doi.org/10.3390/vaccines8020296 - 10 Jun 2020
Cited by 6 | Viewed by 4066
Abstract
This study describes a double-blind randomized placebo-controlled phase I clinical trial in healthy adults of a new potential pandemic H7N9 live attenuated influenza vaccine (LAIV) based on the human influenza virus of Yangtze River Delta hemagglutinin lineage (ClinicalTrials.gov Identifier: NCT03739229). Two doses of [...] Read more.
This study describes a double-blind randomized placebo-controlled phase I clinical trial in healthy adults of a new potential pandemic H7N9 live attenuated influenza vaccine (LAIV) based on the human influenza virus of Yangtze River Delta hemagglutinin lineage (ClinicalTrials.gov Identifier: NCT03739229). Two doses of H7N9 LAIV or placebo were administered intranasally to 30 and 10 subjects, respectively. The vaccine was well-tolerated and not associated with increased rates of adverse events or with any serious adverse events. Vaccine virus was detected in nasal swabs during the 6 days after vaccination or revaccination. A lower frequency of shedding was observed after the second vaccination. Twenty-five clinical viral isolates obtained after the first and second doses of vaccine retained the temperature-sensitive and cold-adapted phenotypic characteristics of LAIV. There was no confirmed transmission of the vaccine strain from vaccinees to placebo recipients. After the two H7N9 LAIV doses, an immune response was observed in 96.6% of subjects in at least one of the assays conducted. Full article
(This article belongs to the Special Issue Influenza Virus and Vaccine Development)
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18 pages, 2310 KiB  
Article
Two Live Attenuated Vaccines against Recent Low–and Highly Pathogenic H7N9 Influenza Viruses Are Safe and Immunogenic in Ferrets
by Larisa Rudenko, Irina Kiseleva, Elena Krutikova, Ekaterina Stepanova, Irina Isakova-Sivak, Svetlana Donina, Andrey Rekstin, Maria Pisareva, Ekaterina Bazhenova, Tatiana Kotomina, Anastasia Katelnikova, Arman Muzhikyan, Valery Makarov, Erin Grace Sparrow and Guido Torelli
Vaccines 2018, 6(4), 74; https://doi.org/10.3390/vaccines6040074 - 1 Nov 2018
Cited by 7 | Viewed by 4471
Abstract
Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically naïve. To be better prepared for the potential occurrence of an H7N9 pandemic, in 2017 the World Health Organization recommended developing candidate vaccine viruses from two new H7N9 viruses, [...] Read more.
Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically naïve. To be better prepared for the potential occurrence of an H7N9 pandemic, in 2017 the World Health Organization recommended developing candidate vaccine viruses from two new H7N9 viruses, A/Guangdong/17SF003/2016 (A/GD) and A/Hong Kong/125/2017 (A/HK). This report describes the development of live attenuated influenza vaccine (LAIV) candidates against A/GD and A/HK viruses and study of their safety and immunogenicity in the ferret model in order to choose the most promising one for a phase I clinical trial. The A/HK-based vaccine candidate (A/17/HK) was developed by classical reassortment in eggs. The A/GD-based vaccine candidate (A/17/GD) was generated by reverse genetics. Ferrets were vaccinated with two doses of LAIV or phosphate-buffered saline. Both H7N9 LAIVs tested were safe for ferrets, as shown by absence of clinical signs, and by virological and histological data; they were immunogenic after a single vaccination. These results provide a compelling argument for further testing of these vaccines in volunteers. Since the A/HK virus represents the cluster that has caused the majority of human cases, and because the A/HK-based LAIV candidate was developed by classical reassortment, this is the preferred candidate for a phase I clinical trial. Full article
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3 pages, 91 KiB  
Article
T Cell-Depleted HlA-Haploidentical Stem Cell Transplantation in Thalassemia Young Patients
by Pietro Sodani, Antonella Isgrò, Javid Gaziev, Katia Paciaroni, Marco Marziali, Maria Domenica Simone, Andrea Roveda, Cecilia Alfieri, Gioa De Angelis, Cristiano Gallucci, Torelli Fabio, Giancarlo Isacchi, Francesco Zinno, Fabiola Landi, Gaspare Adorno, Alessandro Lanti, Manuela Testi, Marco Andreani and Guido Lucarelli
Pediatr. Rep. 2011, 3(s2), e13; https://doi.org/10.4081/pr.2011.s2.e13 - 17 Jun 2011
Cited by 36 | Viewed by 1
Abstract
The cure for thalassemia involves correcting the genetic defect in a hematopoietic stem cell that results in reduced or absent β-globin synthesis and an excess of α-globin dimers. [...] Full article
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